Dr Toby Tuthill

Group Leader

Molecular Biology, Structural biology, Virology

Toby Tuthill is a virologist interested in the molecular mechanisms used by viruses in the picornavirus family. Current areas of interest include cell entry, replication, assembly, structure, antigenicity and evolution. Research is intended to improve our understanding of the biology of these viruses and to apply this knowledge towards improved control of disease.

Toby joined The Pirbright Institute as a Research Fellow in 2009 after ten years postdoctoral experience in the laboratory of Professor Dave Rowlands at the University of Leeds.

News
Publications

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright develops universal foot-and-mouth disease virus test

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Asfor A, Howe N, Grazioli S, Berryman S, Parekh K, Wilsden G, Ludi A, King D, Parida S, Brocchi E, Tuthill T (2020)

Detection of bovine antibodies against a conserved capsid epitope as the basis of a novel universal serological test for foot-and-mouth disease

Journal of Clinical Microbiology 58 (6)

Publisher’s version: https://doi.org/10.1128/JCM.01527-19

Chandler-Bostock R, Mata C P, Bingham R J, Dykeman E C, Meng B, Tuthill T J, Rowlands D J, Ranson N A, Twarock R, Stockley P G (2020)

Assembly of infectious enteroviruses depends on multiple, conserved genomic RNA-coat protein contacts

PLoS Pathogens 16 (12) , e1009146

Publisher’s version: https://doi.org/10.1371/journal.ppat.1009146

Graham S P, McLean R K, Spencer A J, Belij-Rammerstorfer S, Wright D, Ulaszewska M, Edwards J C, Hayes J W P, Martini V, Thakur N, Conceicao C, Dietrich I, Shelton H, Waters R, Ludi A, Wilsden G, Browning C, Bialy D, Bhat S, Stevenson-Leggett P, Hollinghurst P, Gilbride C, Pulido D, Moffat K, Sharpe H, Allen E, Mioulet V, Chiu C, Newman J, Asfor A S, Burman A, Crossley S, Huo J, Owens R J, Carroll M, Hammond J A, Tchilian E, Bailey D, Charleston B, Gilbert S C, Tuthill T J, Lambe T (2020)

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

npj Vaccines 5 (1) , 69

Publisher’s version: https://doi.org/10.1038/s41541-020-00221-3

Tan T K, Rijal P, Rahikainen R, Keeble A H, Schimanski L, Hussain S, Harvey R, Hayes J W P, Edwards J C, McLean R K, Martini V, Pedrera M, Thakur N, Conceicao C, Dietrich I, Shelton H, Ludi A, Wilsden G, Browning C, Zagrajek A K, Bialy D, Bhat S, Stevenson-Leggett P, Hollinghurst P, Tully M, Moffat K, Chiu C, Waters R, Gray A, Azhar M, Mioulet V, Newman J, Asfor A S, Burman A, Crossley S, Hammond J A, Tchilian E, Charleston B, Bailey D, Tuthill T J, Graham S P, Malinauskas T, Huo J, Tree J A, Buttigieg K R, Owens R J, Caroll M W, Daniels R S, McCauley J W, Huang K-Y A, et al (2020)

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

bioRxiv preprint

Publisher’s version: https://doi.org/10.1101/2020.08.31.275701

Ward J C, Lasecka-Dykes L, Neil C, Adeyemi O, Gold S, McLean N, Wright C, Herod M R, Kealy D, Warner E, King D P, Tuthill T J, Rowlands D J, Stonehouse N J (2020)

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome 1 replication but essential for the production of infectious virus.

bioRxiv , 901801

Publisher’s version: https://doi.org/10.1101/2020.01.10.901801

Ferretti L, Di Nardo A, Singer B, Lasecka-Dykes L, Logan G, Wright C F, Pe?rez-Marti?n E, King D P, Tuthill T J, Ribeca P (2018)

Within-host recombination in the foot-and-mouth disease virus genome

Viruses 10 (5) , 221

Publisher’s version: https://dx.doi.org/10.3390/v10050221

Groups

Picornavirus Molecular Biology

Dr Toby Tuthill

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright develops universal foot-and-mouth disease virus test

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Detection of bovine antibodies against a conserved capsid epitope as the basis of a novel universal serological test for foot-and-mouth disease

Assembly of infectious enteroviruses depends on multiple, conserved genomic RNA-coat protein contacts

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome 1 replication but essential for the production of infectious virus.

Within-host recombination in the foot-and-mouth disease virus genome

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Dr Toby Tuthill

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