Dr Toby Tuthill

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Group Leader

Molecular Biology, Structural biology, Virology

Toby Tuthill is a virologist interested in the molecular mechanisms used by viruses in the picornavirus family. Current areas of interest include cell entry, replication, assembly, structure, antigenicity and evolution. Research is intended to improve our understanding of the biology of these viruses and to apply this knowledge towards improved control of disease.

Toby joined The Pirbright Institute as a Research Fellow in 2009 after ten years postdoctoral experience in the laboratory of Professor Dave Rowlands at the University of Leeds.

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Publications

Pirbright scientists investigate pig coronavirus infection to understand COVID-19 in humans

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright develops universal foot-and-mouth disease virus test

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Tuthill T J, Groppelli E, Hogle J M, Rowlands D J (2010)

Picornaviruses.

Current Topics in Microbiology and Immunology (Cell Entry by Non-Enveloped Viruses edited by J E Johnson, Springer) 343 , 43-89

Publisher’s version: http://dx.doi.org/10.1007/82_2010_37

Fry E E, Tuthill T J, Harlos K, Walter T S, Rowlands D J, Stuart D I (2010)

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor

Journal of General Virology 91 (8) , 1971-1977

Publisher’s version: http://dx.doi.org/10.1099/vir.0.020420-0

Groppelli E, Tuthill T J, Rowlands D J (2010)

Cell entry of the aphthovirus equine rhinitis A virus is dependent on endosome acidification

Journal of Virology 84 (12) , 6235-40

Publisher’s version: http://dx.doi.org/10.1128/jvi.02375-09

Walter T S, Ren J, Tuthill T J, Rowlands D J, Stuart D I, Fry E E (2012)

A plate-based high-throughput assay for virus stability and vaccine formulation

Journal of Virological Methods 185 (1) , 166-170

Publisher’s version: http://dx.doi.org/10.1016/j.jviromet.2012.06.014

Tulloch F, Pathania U, Luke G A, Nicholson J, Stonehouse N J, Rowlands D J, Jackson T, Tuthill T, Haas J, Lamond A I, Ryan M D (2014)

FMDV replicons encoding green fluorescent protein are replication competent

Journal of Virological Methods 209 , 35-40

Publisher’s version: http://dx.doi.org/10.1016/j.jviromet.2014.08.020

Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou J J, Rowlands D J, Stonehouse N J, Hogle J M, Tuthill T J (2014)

Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore

PLoS Pathogens 10 (8) , e1004294

Publisher’s version: http://dx.doi.org/10.1371/journal.ppat.1004294

Groups

Picornavirus Molecular Biology

Dr Toby Tuthill

Pirbright scientists investigate pig coronavirus infection to understand COVID-19 in humans

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright develops universal foot-and-mouth disease virus test

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Picornaviruses.

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor

Cell entry of the aphthovirus equine rhinitis A virus is dependent on endosome acidification

A plate-based high-throughput assay for virus stability and vaccine formulation

FMDV replicons encoding green fluorescent protein are replication competent

Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore

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