Dr Toby Tuthill

Group Leader

Molecular Biology, Structural biology, Virology

Toby Tuthill is a virologist interested in the molecular mechanisms used by viruses in the picornavirus family. Current areas of interest include cell entry, replication, assembly, structure, antigenicity and evolution. Research is intended to improve our understanding of the biology of these viruses and to apply this knowledge towards improved control of disease.

Toby joined The Pirbright Institute as a Research Fellow in 2009 after ten years postdoctoral experience in the laboratory of Professor Dave Rowlands at the University of Leeds.

News
Publications

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright develops universal foot-and-mouth disease virus test

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Engineering ‘Fab’ new ways of reducing animal use in foot-and-mouth disease diagnostics

Zhu L, Wang X, Ren J, Kotecha A, Walter T S, Yuan S, Yamashita T, Tuthill T J, Fry E E, Rao Z, Stuart D I (2016)

Structure of human Aichi virus and implications for receptor binding

Nature Microbiology 1 , 16150

Publisher’s version: http://dx.doi.org/10.1038/nmicrobiol.2016.150

Zhu L, Wang X, Ren J, Porta C, Wenham H, Ekstrom J-O, Panjwani A, Knowles N J, Kotecha A, Siebert C A, Lindberg A M, Fry E E, Rao Z, Tuthill T J, Stuart D I (2015)

Structure of Ljungan virus provides insight into genome packaging of this picornavirus

Nature Communications 6 , e8316

Publisher’s version: http://dx.doi.org/10.1038/ncomms9316

Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou J J, Rowlands D J, Stonehouse N J, Hogle J M, Tuthill T J (2014)

Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore

PLoS Pathogens 10 (8) , e1004294

Publisher’s version: http://dx.doi.org/10.1371/journal.ppat.1004294

Tulloch F, Pathania U, Luke G A, Nicholson J, Stonehouse N J, Rowlands D J, Jackson T, Tuthill T, Haas J, Lamond A I, Ryan M D (2014)

FMDV replicons encoding green fluorescent protein are replication competent

Journal of Virological Methods 209 , 35-40

Publisher’s version: http://dx.doi.org/10.1016/j.jviromet.2014.08.020

Walter T S, Ren J, Tuthill T J, Rowlands D J, Stuart D I, Fry E E (2012)

A plate-based high-throughput assay for virus stability and vaccine formulation

Journal of Virological Methods 185 (1) , 166-170

Publisher’s version: http://dx.doi.org/10.1016/j.jviromet.2012.06.014

Fry E E, Tuthill T J, Harlos K, Walter T S, Rowlands D J, Stuart D I (2010)

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor

Journal of General Virology 91 (8) , 1971-1977

Publisher’s version: http://dx.doi.org/10.1099/vir.0.020420-0

Groups

Picornavirus Molecular Biology

Dr Toby Tuthill

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright develops universal foot-and-mouth disease virus test

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Engineering ‘Fab’ new ways of reducing animal use in foot-and-mouth disease diagnostics

Structure of human Aichi virus and implications for receptor binding

Structure of Ljungan virus provides insight into genome packaging of this picornavirus

Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore

FMDV replicons encoding green fluorescent protein are replication competent

A plate-based high-throughput assay for virus stability and vaccine formulation

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor

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Dr Toby Tuthill

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