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Dr Toby Tuthill

Group Leader

Molecular Biology, Structural biology, Virology

Toby Tuthill is a virologist interested in the molecular mechanisms used by viruses in the picornavirus family. Current areas of interest include cell entry, replication, assembly, structure, antigenicity and evolution. Research is intended to improve our understanding of the biology of these viruses and to apply this knowledge towards improved control of disease.

Toby joined The Pirbright Institute as a Research Fellow in 2009 after ten years postdoctoral experience in the laboratory of Professor Dave Rowlands at the University of Leeds.

News
Publications

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Pirbright funding success and award recognition

Engineering ‘Fab’ new ways of reducing animal use in foot-and-mouth disease diagnostics

Breakthrough could make the common cold not so common

Pirbright identifies two new genetic groups of foot-and-mouth disease virus

Walter T S, Ren J, Tuthill T J, Rowlands D J, Stuart D I, Fry E E (2012)

A plate-based high-throughput assay for virus stability and vaccine formulation

Journal of Virological Methods 185 (1) , 166-170

Publisher’s version: http://dx.doi.org/10.1016/j.jviromet.2012.06.014

Fry E E, Tuthill T J, Harlos K, Walter T S, Rowlands D J, Stuart D I (2010)

Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor

Journal of General Virology 91 (8) , 1971-1977

Publisher’s version: http://dx.doi.org/10.1099/vir.0.020420-0

Groppelli E, Tuthill T J, Rowlands D J (2010)

Cell entry of the aphthovirus equine rhinitis A virus is dependent on endosome acidification

Journal of Virology 84 (12) , 6235-40

Publisher’s version: http://dx.doi.org/10.1128/jvi.02375-09

Tuthill T J, Groppelli E, Hogle J M, Rowlands D J (2010)

Picornaviruses.

Current Topics in Microbiology and Immunology (Cell Entry by Non-Enveloped Viruses edited by J E Johnson, Springer) 343 , 43-89

Publisher’s version: http://dx.doi.org/10.1007/82_2010_37

Goodwin S, Tuthill T J, Arias A, Killington R A, Rowlands D J (2009)

Foot-and-mouth disease virus assembly: Processing of recombinant capsid precursor by exogenous protease induces self-assembly of pentamers in vitro in a myristoylation-dependent manner

Journal of Virology 83 (21) , 11275-11282

Publisher’s version: http://dx.doi.org/10.1128/jvi.01263-09

Tuthill T J, Harlos K, Walter T S, Knowles N J, Groppelli E, Rowlands D J, Stuart D I, Fry E E (2009)

Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism?

PLoS Pathogens 5 (10) , e1000620

Publisher’s version: http://dx.doi.org/10.1371/journal.ppat.1000620

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