Dr Toby Tuthill

Group Leader

Molecular Biology, Structural biology, Virology

Toby Tuthill is a virologist interested in the molecular mechanisms used by viruses in the picornavirus family. Current areas of interest include cell entry, replication, assembly, structure, antigenicity and evolution. Research is intended to improve our understanding of the biology of these viruses and to apply this knowledge towards improved control of disease.

Toby joined The Pirbright Institute as a Research Fellow in 2009 after ten years postdoctoral experience in the laboratory of Professor Dave Rowlands at the University of Leeds.

News
Publications

Genetic economy in picornaviruses: foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways

PLoS Pathogens 13 (10) , e1006666

Publisher’s version: http://dx.doi.org/10.1371/journal.ppat.1006666

Logan G, Newman J, Wright C F, Lasecka-Dykes L, Haydon D T, Cottam E M, Tuthill T J (2017)

Deep sequencing of foot-and-mouth disease virus reveals RNA sequences involved in genome packaging

Journal of Virology 92 (1) , e01159-01117

Publisher’s version: http://dx.doi.org/10.1128/JVI.01159-17

Malik N, Kotecha A, Gold S, Asfor A, Ren J, Huiskonen J T, Tuthill T J, Fry E E, Stuart D I (2017)

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

PLOS Pathogens 13 (9) , e1006607

Publisher’s version: https://doi.org/10.1371/journal.ppat.1006607

Newman J, Asfor A S, Berryman S, Jackson T, Curry S, Tuthill T J (2017)

The cellular chaperone heat shock protein 90 is required for foot-and-mouth disease virus capsid precursor processing and assembly of capsid pentamers

Journal of Virology 92 (5) , e01415-01417

Publisher’s version: http://dx.doi.org/10.1128/jvi.01415-17

Panjwani A, Asfor A S, Tuthill T J (2016)

The conserved N-terminus of human rhinovirus capsid protein VP4 contains membrane pore-forming activity and is a target for neutralising antibodies

Journal of General Virology 97 (10) , 3238-3242

Publisher’s version: http://dx.doi.org/10.1099/jgv.0.000629

Shimmon G, Wood B A, Morris A, Mioulet V, Grazioli S, Brocchi E, Berryman S, Tuthill T, King D P, Burman A, Jackson T (2016)

Truncated bovine integrin alpha-v/beta-6 as a universal capture ligand for FMD diagnosis

PLoS ONE 11 (8) , e0160696

Publisher’s version: http://dx.doi.org/10.1371/journal.pone.0160696

Groups

Picornavirus Molecular Biology

Dr Toby Tuthill

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright develops universal foot-and-mouth disease virus test

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Engineering ‘Fab’ new ways of reducing animal use in foot-and-mouth disease diagnostics

Genetic economy in picornaviruses: foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways

Deep sequencing of foot-and-mouth disease virus reveals RNA sequences involved in genome packaging

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

The cellular chaperone heat shock protein 90 is required for foot-and-mouth disease virus capsid precursor processing and assembly of capsid pentamers

The conserved N-terminus of human rhinovirus capsid protein VP4 contains membrane pore-forming activity and is a target for neutralising antibodies

Truncated bovine integrin alpha-v/beta-6 as a universal capture ligand for FMD diagnosis

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Dr Toby Tuthill

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