Prof Bryan Charleston

Real name:

Director

Immunology, Veterinary Practitioner, Virology

Prof Bryan Charleston obtained a BVetMed from the Royal Veterinary College, University of London, UK in 1982. After a period of time in Large Animal Practice, he studied for a Masters degree in Molecular Biology at University College London in 1988, then a PhD degree, as a Wellcome Trust Scholar, from the University of London, UK, in 1991. He then carried out postdoctoral research, as a Wellcome Trust Post-doctoral fellow, at the Royal Veterinary College and the Babraham Institute, Cambridge for three years.

He joined The Pirbright Institute in 1994 and focused on studies of the immune response to viral infections in cattle. In addition, he provided advice and expertise on the design of infectious disease challenge models for a wide range of pathogens in important agricultural species. His research is focused on understanding the immune response to foot-and–mouth disease virus (FMDV) in cattle to develop novel vaccines.

News
Publications

The glycosylation pattern of baculovirus expressed envelope protein E2 affects its ability to prevent infection with bovine viral diarrhoea virus

Virus Research 114 (1-2) , 54-62

Publisher’s version: http://dx.doi.org/10.1016/j.virusres.2005.05.011

Brackenbury L S, Carr B V, Stamataki Z, Prentice H, Lefevre E A, Howard C J, Charleston B (2005)

Identification of a cell population that produces alpha/beta interferon in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus

Journal of Virology 79 , 7738-7744

Publisher’s version: http://dx.doi.org/10.1128/jvi.79.12.7738-7744.2005

Parida S, Oh Y, Reid S M, Cox S J, Statham R J, Mahapatra M, Anderson J, Barnett P V, Charleston B, Paton D J (2006)

Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV

Vaccine 24 (7) , 964-969

Publisher’s version: http://dx.doi.org/10.1016/j.vaccine.2005.08.108

Gerner W, Carr B V, Wiesmueller K H, Pfaff E, Saalmueller A, Charleston B (2007)

Identification of a novel foot-and-mouth disease virus specific T-cell epitope with immunodominant characteristics in cattle with MHC serotype A31

Veterinary Research 38 (4) , 565-572

Publisher’s version: http://dx.doi.org/10.1051/vetres:2007016

Guzman E, Taylor G, Charleston B, Skinner M A, Ellis S A (2008)

An MHC-restricted CD8+ T-cell response is induced in cattle by foot-and-mouth-disease virus (FMDV) infection following vaccination with inactivated FMDV

Journal of General Virology 89 (3) , 667-675

Publisher’s version: http://dx.doi.org/10.1099/vir.0.83417-0

Juleff N, Windsor M, Reid E, Seago J, Zhang Z, Monaghan P, Morrison I W, Charleston B (2008)

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Viral Immunology

Prof Bryan Charleston

Pirbright strengthens animal disease partnership with India

Veterinary Vaccine Centre welcomed in White Paper

Pirbright and VIDO expands collaboration to advance vaccine manufacturing

Professor Bryan Charleston elected as Fellow of the Royal Society

Pirbright showcases the best in science and community with open-door event

The glycosylation pattern of baculovirus expressed envelope protein E2 affects its ability to prevent infection with bovine viral diarrhoea virus

Identification of a cell population that produces alpha/beta interferon in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus

Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV

Identification of a novel foot-and-mouth disease virus specific T-cell epitope with immunodominant characteristics in cattle with MHC serotype A31

An MHC-restricted CD8+ T-cell response is induced in cattle by foot-and-mouth-disease virus (FMDV) infection following vaccination with inactivated FMDV

Foot-and-mouth disease virus persists in the light zone of germinal centres

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