Prof Bryan Charleston

Director

Immunology, Veterinary Practitioner, Virology

Prof Bryan Charleston obtained a BVetMed from the Royal Veterinary College, University of London, UK in 1982. After a period of time in Large Animal Practice, he studied for a Masters degree in Molecular Biology at University College London in 1988, then a PhD degree, as a Wellcome Trust Scholar, from the University of London, UK, in 1991. He then carried out postdoctoral research, as a Wellcome Trust Post-doctoral fellow, at the Royal Veterinary College and the Babraham Institute, Cambridge for three years.

He joined The Pirbright Institute in 1994 and focused on studies of the immune response to viral infections in cattle. In addition, he provided advice and expertise on the design of infectious disease challenge models for a wide range of pathogens in important agricultural species. His research is focused on understanding the immune response to foot-and–mouth disease virus (FMDV) in cattle to develop novel vaccines.

News
Publications

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Pirbright scientists shed new light on foot-and-mouth disease virus evolution

Pirbright enters bioimaging collaboration with Diamond Light Source

One Health Day: Pirbright research to protect animals and humans

Juleff N, Windsor M, Reid E, Seago J, Zhang Z, Monaghan P, Morrison I W, Charleston B (2008)

Foot-and-mouth disease virus persists in the light zone of germinal centres

PLoS One 3 (10) , e3434

Publisher’s version: http://dx.doi.org/10.1371/journal.pone.0003434

Gerner W, Carr B V, Wiesmueller K H, Pfaff E, Saalmueller A, Charleston B (2007)

Identification of a novel foot-and-mouth disease virus specific T-cell epitope with immunodominant characteristics in cattle with MHC serotype A31

Veterinary Research 38 (4) , 565-572

Publisher’s version: http://dx.doi.org/10.1051/vetres:2007016

Meyers G, Ege A, Fetzer C, von Freyburg M, Elbers K, Carr V, Prentice H, Charleston B, Schurmann E M (2007)

Bovine viral diarrhea virus: prevention of persistent fetal infection by a combination of two mutations affecting Erns RNase and Npro protease

Journal of Virology 81 (7) , 3327-3338

Publisher’s version: http://dx.doi.org/10.1128/JVI.02372-06

Pillai M R, Lefevre E A, Carr B V, Charleston B, O'Grady P (2007)

Workshop cluster 1, a gammadelta T cell specific receptor is phosphorylated and down regulated by activation induced Src family kinase activity

Molecular Immunology 44 (7) , 1691-1703

Publisher’s version: http://dx.doi.org/10.1016/j.molimm.2006.08.009

Seago J, Hilton L, Reid E, Doceul V, Jeyatheesan J, Moganeradj K, McCauley J, Charleston B, Goodbourn S (2007)

The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3

Journal of General Virology 88 (11) , 3002-3006

Publisher’s version: http://dx.doi.org/10.1099/vir.0.82934-0

Parida S, Oh Y, Reid S M, Cox S J, Statham R J, Mahapatra M, Anderson J, Barnett P V, Charleston B, Paton D J (2006)

Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV

Vaccine 24 (7) , 964-969

Publisher’s version: http://dx.doi.org/10.1016/j.vaccine.2005.08.108

Groups

Viral Immunology

Prof Bryan Charleston

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

Pirbright scientists shed new light on foot-and-mouth disease virus evolution

Pirbright enters bioimaging collaboration with Diamond Light Source

One Health Day: Pirbright research to protect animals and humans

Foot-and-mouth disease virus persists in the light zone of germinal centres

Identification of a novel foot-and-mouth disease virus specific T-cell epitope with immunodominant characteristics in cattle with MHC serotype A31

Bovine viral diarrhea virus: prevention of persistent fetal infection by a combination of two mutations affecting Erns RNase and Npro protease

Workshop cluster 1, a gammadelta T cell specific receptor is phosphorylated and down regulated by activation induced Src family kinase activity

The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3

Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV

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Prof Bryan Charleston

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