Prof Bryan Charleston

Director

Immunology, Veterinary Practitioner, Virology

Prof Bryan Charleston obtained a BVetMed from the Royal Veterinary College, University of London, UK in 1982. After a period of time in Large Animal Practice, he studied for a Masters degree in Molecular Biology at University College London in 1988, then a PhD degree, as a Wellcome Trust Scholar, from the University of London, UK, in 1991. He then carried out postdoctoral research, as a Wellcome Trust Post-doctoral fellow, at the Royal Veterinary College and the Babraham Institute, Cambridge for three years.

He joined The Pirbright Institute in 1994 and focused on studies of the immune response to viral infections in cattle. In addition, he provided advice and expertise on the design of infectious disease challenge models for a wide range of pathogens in important agricultural species. His research is focused on understanding the immune response to foot-and–mouth disease virus (FMDV) in cattle to develop novel vaccines.

News
Publications

Pirbright scientists shed new light on foot-and-mouth disease virus evolution

Pirbright enters bioimaging collaboration with Diamond Light Source

One Health Day: Pirbright research to protect animals and humans

Pirbright collaboration proves Rift Valley fever vaccine safe in pregnant animals

Pirbright grants licence for new foot-and-mouth disease vaccine

Pillai M R, Lefevre E A, Carr B V, Charleston B, O'Grady P (2007)

Workshop cluster 1, a gammadelta T cell specific receptor is phosphorylated and down regulated by activation induced Src family kinase activity

Molecular Immunology 44 (7) , 1691-1703

Publisher’s version: http://dx.doi.org/10.1016/j.molimm.2006.08.009

Seago J, Hilton L, Reid E, Doceul V, Jeyatheesan J, Moganeradj K, McCauley J, Charleston B, Goodbourn S (2007)

The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3

Journal of General Virology 88 (11) , 3002-3006

Publisher’s version: http://dx.doi.org/10.1099/vir.0.82934-0

Parida S, Oh Y, Reid S M, Cox S J, Statham R J, Mahapatra M, Anderson J, Barnett P V, Charleston B, Paton D J (2006)

Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV

Vaccine 24 (7) , 964-969

Publisher’s version: http://dx.doi.org/10.1016/j.vaccine.2005.08.108

Brackenbury L S, Carr B V, Stamataki Z, Prentice H, Lefevre E A, Howard C J, Charleston B (2005)

Identification of a cell population that produces alpha/beta interferon in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus

Journal of Virology 79 , 7738-7744

Publisher’s version: http://dx.doi.org/10.1128/jvi.79.12.7738-7744.2005

Pande A, Carr B V, Wong S Y C, Dalton K, Jones I M, McCauley J W, Charleston B (2005)

The glycosylation pattern of baculovirus expressed envelope protein E2 affects its ability to prevent infection with bovine viral diarrhoea virus

Virus Research 114 (1-2) , 54-62

Publisher’s version: http://dx.doi.org/10.1016/j.virusres.2005.05.011

Brackenbury L S, Carr B V, Charleston B (2003)

Aspects of the innate and adaptive immune responses to acute infections with BVDV

Veterinary Microbiology 96 , 337-344

Publisher’s version: http://dx.doi.org/10.1016/j.vetmic.2003.09.004

Groups

Viral Immunology

Prof Bryan Charleston

Pirbright scientists shed new light on foot-and-mouth disease virus evolution

Pirbright enters bioimaging collaboration with Diamond Light Source

One Health Day: Pirbright research to protect animals and humans

Pirbright collaboration proves Rift Valley fever vaccine safe in pregnant animals

Pirbright grants licence for new foot-and-mouth disease vaccine

Workshop cluster 1, a gammadelta T cell specific receptor is phosphorylated and down regulated by activation induced Src family kinase activity

The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3

Interferon-gamma production in vitro from whole blood of foot-and-mouth disease virus (FMDV) vaccinated and infected cattle after incubation with inactivated FMDV

Identification of a cell population that produces alpha/beta interferon in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus

The glycosylation pattern of baculovirus expressed envelope protein E2 affects its ability to prevent infection with bovine viral diarrhoea virus

Aspects of the innate and adaptive immune responses to acute infections with BVDV

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