Dr Katy Moffat

Postdoctoral Scientist

Bioimaging, Cell Biology, Immunology

Katy Moffat studied for her BSc Hons in Biochemistry at Stirling University and then completed her PhD at the John Innes centre, studying the effects of gene silencing on virus infection in plants. She joined the Immunology group at The Pirbright Institute in 2001 to examine interactions between foot-and-mouth disease virus (FMDV) and intracellular proteins during virus replication.

Katy discovered that FMDV infection lead to a disruption of the cellular protein secretory pathway and the viral protein responsible differed to that of another picornavirus, Poliovirus. In 2006, Katy became part of the Vaccinology group and is currently studying responses of dendritic cells (immune cells) to bluetongue virus (BTV) infection.

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Tel. 01483 232441

katy.moffat@pirbright.ac.uk

Pirbright scientists show two peste des petits ruminants vaccines protect against all strains

New vaccine technique targets multiple poultry diseases

Hodgson S, Moffat K, Hill H, Flannery J T, Graham S P, Baron M D, Darpel K E (2018)

Comparison of the immunogenicity and cross-lineage efficacy of live attenuated peste des petits ruminants virus vaccines PPRV/Nigeria/75/1 and PPRV/Sungri/96

Journal of Virology early view,

Publisher’s version: https://doi.org/10.1128/JVI.01471-18

Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, Shen Z, Nair V, Yao Y (2018)

A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system

Vaccine 36 (5), 716-722

Publisher’s version: https://dx.doi.org/10.1016/j.vaccine.2017.12.025

Berryman S, Moffat K, Harak C, Lohmann V, Jackson T (2016)

Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol-4-kinases

Journal of General Virology 97 (8), 1841-1852

Publisher’s version: http://dx.doi.org/10.1099/jgv.0.000485

Darpel K E, Barber J, Hope A, Wilson A J, Gubbins S, Henstock M, Frost L, Batten C, Veronesi E, Moffat K, Carpenter S, Oura C, Mellor P S, Mertens P P C (2016)

Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts

Scientific Reports 6, 20627

Publisher’s version: http://dx.doi.org/10.1038/srep20627

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