Dr Katy Moffat

Real name:

Postdoctoral Scientist

Bioimaging, Cell Biology, Immunology

Katy Moffat studied for her BSc Hons in Biochemistry at Stirling University and then completed her PhD at the John Innes centre, studying the effects of gene silencing on virus infection in plants. She joined the Immunology group at The Pirbright Institute in 2001 to examine interactions between foot-and-mouth disease virus (FMDV) and intracellular proteins during virus replication.

Katy discovered that FMDV infection lead to a disruption of the cellular protein secretory pathway and the viral protein responsible differed to that of another picornavirus, Poliovirus. In 2006, Katy became part of the Vaccinology group and is currently studying responses of dendritic cells (immune cells) to bluetongue virus (BTV) infection.

News
Publications

Pirbright scientists use ‘molecular magnets’ to discover FMD virus segments that could improve vaccine effectiveness

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Pirbright study shows how SARS-CoV-2 could have adapted from bats to humans and which other animals it could infect

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

Fay, PC, Wijesiriwardana, N, Munyanduki, H, Sanz-Bernardo, B, Lewis, I, Haga, IR, Moffat, K, van Vliet, AHM, Hope, J, Graham, SP and Beard, PM (2022)

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

Frontiers in Immunology 13 , 1051008

Publisher’s version: https://doi.org/10.3389/fimmu.2022.1051008

Roos E O, Bonnet-Di Placido M, Mwangi W N, Moffat K, Fry L M, Waters R, Hammond J A (2022)

OMIP-085: Cattle B-cell phenotyping by an 8-color panel

Cytometry A early view

Publisher’s version: https://doi.org/10.1002/cyto.a.24683

Roy S, Bondada M S, Zhang Y, Moffat K, Nair V, Yao Y (2022)

Proviral ALV-LTR sequence is essential for continued proliferation of the ALV-transformed B cell line

International Journal of Molecular Sciences 23 (19)

Publisher’s version: https://doi.org/10.3390/ijms231911263

Rathakrishnan A, Connell S, Petrovan V, Moffat K, Goatley L C, Jabbar T, Sanchez-Cordon P J, Reis A L, Dixon L K (2022)

Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication, virulence and induction of protection

Journal of Virology 96 (6) , e0189921

Publisher’s version: https://doi.org/10.1128/jvi.01899-21

Childs K, Juleff N, Moffat K, Seago J (2021)

Demonstration of co-infection and trans-encapsidation of viral RNA in vitro using epitope-tagged foot-and-mouth disease viruses.

Viruses 13 (12) , 2433

Publisher’s version: https://www.mdpi.com/1999-4915/13/12/2433

Petrovan V, Rathakrishnan A, Islam M, Goatley L C, Moffat K, Sanchez-Cordon P J, Reis A L, Dixon L K (2022)

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

Journal of Virology 96 (1) , e0134021

Publisher’s version: https://doi.org/10.1128/JVI.01340-21

Groups

Bioimaging

Dr Katy Moffat

Pirbright scientists use ‘molecular magnets’ to discover FMD virus segments that could improve vaccine effectiveness

Pirbright generates first pig flu antibodies that could improve human treatments and guide flu vaccine selection

Early animal studies by Pirbright and Oxford yield promising results for new potential COVID-19 vaccine

Pirbright study shows how SARS-CoV-2 could have adapted from bats to humans and which other animals it could infect

Studies at Pirbright demonstrate two doses of Oxford University’s COVID-19 vaccine boosts immune response in pigs

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

OMIP-085: Cattle B-cell phenotyping by an 8-color panel

Proviral ALV-LTR sequence is essential for continued proliferation of the ALV-transformed B cell line

Differential effect of deleting members of African swine fever virus multigene families 360 and 505 from the genotype II Georgia 2007/1 isolate on virus replication, virulence and induction of protection

Demonstration of co-infection and trans-encapsidation of viral RNA in vitro using epitope-tagged foot-and-mouth disease viruses.

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

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