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Development of a high-throughput ex-vivo burn wound model using porcine skin, and its application to evaluate new approaches to control wound infection

Biofilm formation in wounds is considered a major barrier to successful treatment, and has been associated with the transition of wounds to a chronic non-healing state. Here, we present a novel laboratory model of wound biofilm formation using ex-vivo porcine skin and a…

The Pirbright Institute opens new laboratory doors to the public

This weekend, pupils from Pirbright Village Primary School, Pirbright Parish Council and more than 120 other visitors from the local community were able to glimpse behind the scenes at The Pirbright Institute’s new high biocontainment facilities – an over £100 million…

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Biological characterization of wild-bird-origin avian avulavirus 1 and efficacy of currently applied vaccines against potential infection in commercial poultry

Newcastle disease virus (NDV), the type member of the species Avian avulavirus 1 (formerly known as avian paramyxovirus serotype 1), causes a highly contagious and economically important disease in a myriad of avian species around the globe. While extensive vaccination…

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Nomenclature for the KIR of non-human species

The increasing number of Killer Immunoglobulin-like Receptor (KIR) sequences available for non-human primate species and cattle has prompted development of a centralized database, guidelines for a standardized nomenclature, and minimum requirements for database submission…

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The unique evolution of the pig LRC, a single KIR but expansion of LILR and a novel Ig receptor family

The leukocyte receptor complex (LRC) encodes numerous immunoglobulin (Ig)-like receptors involved in innate immunity. These include the killer-cell Ig-like receptors (KIR) and the leukocyte Ig-like receptors (LILR) which can be polymorphic and vary greatly in number between…

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Marek's disease virus oncoprotein Meq physically interacts with the chicken infectious anemia virus-encoded apoptotic protein apoptin

Marek's disease (MD) is a neoplastic disease of poultry caused by Marek's disease virus (MDV), a highly contagious alphaherpesvirus. Meq, the major MDV oncoprotein, induces neoplastic transformation of T-cells through several mechanisms, including inhibition of apoptosis. In…

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Assessing the variability in transmission of bovine tuberculosis within Spanish cattle herds

In Spain, despite years of efforts to eradicate bovine tuberculosis (bTB), the disease is still endemic, with some areas of high prevalence. In this context, the surveillance and control plans may need to be re-evaluated, and understanding the dynamics of bTB spread within…

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Universality classes of interaction structures for NK fitness landscapes

Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of L binary loci. The fitness assigned…

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Supplementation of Vitamin E protects chickens from Newcastle disease virus-mediated exacerbation of intestinal oxidative stress and tissue damage

Newcastle disease virus (NDV) causes a highly devastating and contagious disease in poultry, which is mainly attributed to extensive tissue damages in the digestive, respiratory and nervous systems. However, nature and dynamics of NDV-induced oxidative stresses in the…

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The S2 subunit of infectious bronchitis virus Beaudette is a determinant of cellular tropism

The spike glycoprotein (S) of the avian gammacoronavirus, infectious bronchitis virus (IBV), is comprised of two subunits, S1 and S2, and has a role in virulence in vivo as well as being responsible for cellular tropism in vitro We have previously demonstrated that…