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Identification of novel B-cell epitope in gp85 of subgroup J avian leukosis virus and its application in diagnosis of disease

The gp85 is the main envelope protein of avian leukosis subgroup J (ALV-J) involved in virus neutralization. Here, we mapped the epitope in ALV-J gp85 by ELISA using synthetic peptides and developed epitope based diagnostic methods for ALV-J infection.

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Comparison of the immunogenicity and cross-lineage efficacy of live attenuated peste des petits ruminants virus vaccines PPRV/Nigeria/75/1 and PPRV/Sungri/96

Peste des petits ruminants (PPR) is a severe disease of goats and sheep that is widespread in Africa, the Middle East and Asia. Several effective vaccines exist for the disease, based on attenuated strains of the virus (PPRV) that causes PPR. While the efficacy of these…

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An ex vivo chicken primary bursal-cell culture model to study infectious bursal disease virus pathogenesis

Infectious bursal disease virus (IBDV) is a birnavirus of economic importance to the poultry industry. The virus infects B cells, causing morbidity, mortality, and immunosuppression in infected birds. In this study, we describe the isolation of chicken primary bursal cells…

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Reconstructing the evolutionary history of pandemic foot-and-mouth disease viruses: the impact of recombination within the emerging O/ME-SA/Ind-2001 lineage

Foot-and-mouth disease (FMD) is a highly contagious disease of livestock affecting animal production and trade throughout Asia and Africa. Understanding FMD virus (FMDV) global movements and evolution can help to reconstruct the disease spread between endemic regions and…

influenza virus coloured orange and purple

H7N9 flu mutation identified that allows immune system escape

Scientists at The Pirbright Institute have identified a key mutation in the H7N9 avian influenza virus which could allow it to escape immune system defences, reducing the effectiveness of vaccines. The research, published in the Journal of Virology, demonstrated that small…

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Pirbright scientists use ground-breaking techniques to identify how a ruminant virus can adapt to infect human cells

Scientists from The Pirbright Institute have used a ground-breaking approach to identify that a morbillivirus that causes disease in small ruminants such as sheep and goats, known as peste des petits ruminants (a close relative of measles virus – the human morbillivirus)…

Ada Lovelace Day: Celebrating women in science

To celebrate Ada Lovelace Day, today 9 October, we asked everyone at Pirbright to nominate their female STEM role model with a short explanation on why they were nominating them. Miriam Windsor, Research Services Capability Leader, nominated Pirbright’s Dr Geraldine Taylor…

Ada Lovelace Day: Celebrating women in science

To celebrate Ada Lovelace Day, today 9 October, we asked everyone at Pirbright to nominate their female STEM role model with a short explanation on why they were nominating them. Miriam Windsor, Research Services Capability Leader, nominated Pirbright’s Dr Geraldine Taylor…

Pirbright scientists produce lab technique which reduces need for experimental chickens

Scientists from The Pirbright Institute have created a laboratory procedure which allows the response of chicken immune cells to infectious bursal disease virus (IBDV) to be studied without infecting live chickens. IBDV, also known as Gumboro disease, can result in…

foot-and-mouth disease spread from the indian subcontinent reconstructed through genetic analysis

Pirbright collaboration maps foot-and-mouth disease escape from Indian subcontinent

Scientists from The Pirbright Institute have used state-of-the-art approaches to monitor foot-and-mouth disease (FMD) outbreaks that have recently radiated out from the Indian subcontinent. The seven different types of FMD virus (called serotypes) can be split further into…