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Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses

The PA-X protein of influenza A virus has roles in host cell shut-off and viral pathogenesis. While most strains are predicted to encode PA-X, strain-dependent variations in activity have been noted. We found that PA-X protein from A/PR/8/34 (PR8) strain had significantly…

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The molecular basis of antigenic variation among A(H9N2) avian influenza viruses

Avian influenza A(H9N2) viruses are an increasing threat to global poultry production and, through zoonotic infection, to human health where they are considered viruses with pandemic potential. Vaccination of poultry is a key element of disease control in endemic countries…

Claire colenutt receiving innovation in animal healthcare award

Pirbright scientist wins Innovation Award

Dr Claire Colenutt received the Innovation in Animal Healthcare award on Monday 3 December 2018 at the Guildford Innovation Awards 2018. Dr Colenutt won the award for the creation of a new foot-and-mouth disease virus (FMDV) field test, which could improve disease…

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The effects of in ovo administration of encapsulated Toll-like receptor 21 ligand as an adjuvant with Marek's disease vaccine

Marek's Disease Virus (MDV) is the causative agent of a lymphoproliferative disease, Marek's disease (MD) in chickens. MD is only controlled by mass vaccination; however, immunity induced by MD vaccines is unable to prevent MDV replication and transmission. The herpesvirus…

Antibody

Pirbright hosts inaugural immunology meeting

The Pirbright Institute hosted the inaugural Comparative Veterinary Immunology Group (CVIG) meeting ‘ Frontiers in Human and Veterinary Antibody discovery’ on 26 and 27 November, 2018 where 120 renowned immunologists from around the world congregated to share knowledge and…

Pirbright student wins award to study the role of insects in lumpy skin disease infection

First year PhD student Charlotte Cook was recently thrilled to learn that she is being given an In Vivo Skills Award from the Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation (UKRI). Only three such awards are offered by the…

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The development of two field-ready reverse transcription loop-mediated isothermal amplification assays for the rapid detection of Seneca Valley virus 1

Seneca Valley virus 1 (SVV-1) has been associated with vesicular disease in swine, with clinical signs indistinguishable from those of other notifiable vesicular diseases such as foot-and-mouth disease. Rapid and accurate detection of SVV-1 is central to confirm the disease…

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Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis

IFNγ is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFNγ receptor (IFNγR -/-) at a dose which caused severe disease in wild type 129Sv/Ev (WT) mice resulted in…

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Evolution of codon usage bias in henipaviruses is governed by natural selection and is host-specific

Hendra virus (HeV) and Nipah virus (NiV) are among a group of emerging bat-borne paramyxoviruses that have crossed their species-barrier several times by infecting several hosts with a high fatality rate in human beings. Despite the fatal nature of their infection, a…

inter institute imaging group

Pirbright hosts first Inter-Institute Imaging Network

The first meeting of the Inter-Institute Imaging Network (IIIN) was recently held at The Pirbright Institute to promote collaboration between its partners in the field of bioimaging. Delegates from the Biotechnology and Biological Sciences Research Council institutes and…