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Pirbright to be part of new £6.2M poultry viruses project

Researchers from The Pirbright Institute, led by Head of the Avian Viral Diseases Programme, Professor Venugopal Nair, are to be part of a £6.2M BBSRC-funded project to develop rapid responses to emerging poultry viruses. The funding boost will also help to establish the…

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Application of CRISPR/Cas9 gene editing system on MDV-1 genome for the study of gene function

Marek's disease virus (MDV) is a member of alphaherpesviruses associated with Marek's disease, a highly contagious neoplastic disease in chickens. Complete sequencing of the viral genome and recombineering techniques using infectious bacterial artificial chromosome (BAC)…

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Synergistic viral replication of Marek's disease virus and avian leukosis virus subgroup J is responsible for the enhanced pathogenicity in the superinfection of chickens

Superinfection of Marek's disease virus (MDV) and avian leukosis virus subgroup J (ALV-J) causes lethal neoplasia and death in chickens. However, whether there is synergism between the two viruses in viral replication and pathogenicity has remained elusive. In this study, we…

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Serological and clinical evaluation of the Yugoslavian RM65 sheep pox strain vaccine use in cattle against lumpy skin disease

Lumpy skin disease (LSD) is an emerging infectious disease of cattle. Since 2012, it has been seen throughout the Middle East region. The aim of this study was to compare the humoral response of three different dosages of the RM65 sheep pox (SPP) vaccine to assess the use of…

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In ovo administration of Toll-like receptor ligands encapsulated in PLGA nanoparticles impede tumor development in chickens infected with Marek's disease virus

One of the economically important diseases in the poultry industry is Marek's disease (MD) which is caused by Marek's disease virus (MDV). The use of current vaccines provides protection against clinical signs of MD in chickens. However, these vaccines do not prevent the…

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Assessing the probability of introduction and transmission of lumpy skin disease virus within the United Kingdom

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The ADRP domain from a virulent strain of Infectious Bronchitis Virus is not sufficient to confer a pathogenic phenotype to the attenuated Beaudette

The replicase gene of the coronavirus infectious bronchitis virus (IBV) encodes 15 non-structural proteins (nsps). Nsp 3 is a multi-functional protein containing a conserved ADP-ribose-1''-phosphatase (ADRP) domain. The crystal structures of the domain from two strains of…

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Spotlight on avian pathology: Marek’s disease

Marek's disease (MD), characterised by rapid-onset lymphoid tumours, immunosuppression and paralysis, is one of the most widespread economically important disease of poultry world-wide. Caused by the highly contagious Marek's disease virus (MDV), control of MD is mainly…

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Comparative analysis of adaptive immune responses following experimental infections of cattle with bovine viral diarrhoea virus-1 and an Asiatic atypical ruminant pestivirus

Atypical ruminant pestiviruses are closely related to the two bovine viral diarrhoea virus (BVDV) species, BVDV-1 and BVDV-2. While there is evidence of cross-protective immune responses between BVDV-1 and BVDV-2, despite antigenic differences, there is little information on…

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Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles

Highly pathogenic avian influenza (HPAI) A(H5N1) viruses pose a significant economic burden to the poultry industry worldwide and have pandemic potential. Poultry vaccination against HPAI A(H5N1) viruses has been an important component of HPAI control measures and has been…