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Pirbright switches it up: creating foot-and-mouth disease hybrids for better vaccines

In collaborative research led by The Pirbright Institute, scientists have generated a ‘hybrid’ foot-and-mouth disease virus (FMDV) with improved stability, which will increase its effectiveness when administered as a vaccine. They targeted the Southern African Territories…

foot-and-mouth disease virus pink blue grey

Pirbright switches it up: creating foot-and-mouth disease hybrids for better vaccines

In collaborative research led by The Pirbright Institute, scientists have generated a ‘hybrid’ foot-and-mouth disease virus (FMDV) with improved stability, which will increase its effectiveness when administered as a vaccine. They targeted the Southern African Territories…

A revival for comparative and veterinary immunology

Under the leadership of Pirbright’s Dr Elma Tchilian the Comparative and Veterinary Immunology Group (CVIG) has been revived and is actively engaging in opportunities to showcase the research of its members and bring knowledge of comparative and veterinary immunology to a…

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Impact of foot-and-mouth disease on fertility performance in a large dairy herd in Kenya

This was a retrospective cohort study using data collected from a large-scale dairy herd in Kenya (n = 328 female animals), to investigate the effects of foot-and-mouth disease (FMD) on herd fertility performance following a confirmed outbreak in a regularly vaccinated herd…

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Infectious bronchitis virus nonstructural protein 4 alone induces membrane pairing

Positive-strand RNA viruses, such as coronaviruses, induce cellular membrane rearrangements during replication to form replication organelles allowing for efficient viral RNA synthesis. Infectious bronchitis virus (IBV), a pathogenic avian Gammacoronavirus of significant…

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Infectious bronchitis virus nonstructural protein 4 alone induces membrane pairing

Positive-strand RNA viruses, such as coronaviruses, induce cellular membrane rearrangements during replication to form replication organelles allowing for efficient viral RNA synthesis. Infectious bronchitis virus (IBV), a pathogenic avian Gammacoronavirus of significant…

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Recent advances in threshold-dependent gene drives for mosquitoes

Mosquito-borne diseases, such as malaria, dengue and chikungunya, cause morbidity and mortality around the world. Recent advances in gene drives have produced control methods that could theoretically modify all populations of a disease vector, from a single release, making…

Peste-des-petits ruminants vaccine differentiation group from Pirbright in Chennai, India

Pirbright scientists run vaccination campaign to eradicate peste des petits ruminants

Scientists from The Pirbright Institute’s Vaccine Differentiation group have recently returned from Chennai in India, where they conducted a mass peste des petits ruminants (PPR) vaccination campaign and awareness programme. They joined scientists from four specialist…

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Culicoides species composition and abundance on Irish cattle farms: implications for arboviral disease transmission

Following the emergence of Schmallenberg virus (SBV) in Ireland in 2012, a sentinel herd surveillance program was established in the south of Ireland with the primary aim of investigating the species composition and abundance of Culicoides on livestock farms in the region…

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Monoclonal antibody resistant mutant of Peste des petits ruminants vaccine virus

The available vaccines for control of Peste des petits ruminants do not favour differentiation of infected and vaccinated animals (DIVA). Hence, the present study was aimed to isolate and characterize monoclonal antibody resistant mutant of an Indian strain of vaccine virus…