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Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018

Significant progress has been made over the last decade in defining major histocompatibility complex (MHC) diversity at the nucleotide, allele, haplotype, diplotype, and population levels in many non-human species. Much of this progress has been driven by the increased…

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Systematic literature review of Rift Valley fever virus seroprevalence in livestock, wildlife and humans in Africa from 1968 to 2016

BACKGROUND: Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes severe disease in livestock and humans. The virus has caused recurrent outbreaks in Africa and the Arabian Peninsula since its discovery in 1931. This review sought to evaluate RVFV seroprevalence…

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Systematic literature review of Rift Valley fever virus seroprevalence in livestock, wildlife and humans in Africa from 1968 to 2016

BACKGROUND: Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes severe disease in livestock and humans. The virus has caused recurrent outbreaks in Africa and the Arabian Peninsula since its discovery in 1931. This review sought to evaluate RVFV seroprevalence…

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Potential of genotype VII Newcastle disease viruses to cause differential infections in chickens and ducks

Newcastle disease (ND), caused by ND virus (NDV), is one of the most infectious and economically important diseases of the poultry industry worldwide. While infections are reported in a wide range of avian species, the pathogenicity of chicken-origin virulent NDV isolates in…

Research could lead to low cost infectious bronchitis vaccine production

Infectious bronchitis is the most economically important infectious disease affecting chickens in the UK, and remains a major problem in the global poultry industry despite the existence of many different vaccines. Infectious bronchitis virus (IBV) vaccines are currently…

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The S2 subunit of infectious bronchitis virus Beaudette is a determinant of cellular tropism

The spike glycoprotein (S) of the avian gammacoronavirus, infectious bronchitis virus (IBV), is comprised of two subunits, S1 and S2, and has a role in virulence in vivo as well as being responsible for cellular tropism in vitro We have previously demonstrated that…

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The S2 subunit of infectious bronchitis virus Beaudette is a determinant of cellular tropism

The spike glycoprotein (S) of the avian gammacoronavirus, infectious bronchitis virus (IBV), is comprised of two subunits, S1 and S2, and has a role in virulence in vivo as well as being responsible for cellular tropism in vitro We have previously demonstrated that…

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Production, characterization, and epitope mapping of a monoclonal antibody against genotype VII Newcastle disease virus V protein

Newcastle disease virus (NDV) V protein is crucial for viral interferon (IFN) antagonism and virulence, determining its host range restriction. However, little information is available on the B cell epitopes of V protein and the subcellular movement of V protein in the…

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IPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era

The IPD-MHC Database is the official repository for non-human MHC sequences, overseen and supported by the Comparative MHC Nomenclature Committee, providing access to curated MHC data and associated analysis tools. To address the increasing amount and complexity of data…

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Foot and mouth disease vaccine strain selection: Current approaches and future perspectives

Lack of cross protection between foot and mouth disease (FMD) virus (FMDV) serotypes as well as incomplete protection between some subtypes of FMDV affect the application of vaccine in the field. Further, the emergence of new variant FMD viruses periodically makes the…