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Rinderpest eradication: challenges for remaining disease free and implications for future eradication efforts

In 2011, the World Organisation for Animal Health (OIE) and the Food and Agriculture Organization of the United Nations (FAO) declared global freedom from rinderpest, formally announcing that rinderpest virus infections had been eliminated from susceptible livestock…

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Marek's disease virus oncoprotein Meq physically interacts with the chicken infectious anemia virus-encoded apoptotic protein apoptin

Marek's disease (MD) is a neoplastic disease of poultry caused by Marek's disease virus (MDV), a highly contagious alphaherpesvirus. Meq, the major MDV oncoprotein, induces neoplastic transformation of T-cells through several mechanisms, including inhibition of apoptosis. In…

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Assessing the variability in transmission of bovine tuberculosis within Spanish cattle herds

In Spain, despite years of efforts to eradicate bovine tuberculosis (bTB), the disease is still endemic, with some areas of high prevalence. In this context, the surveillance and control plans may need to be re-evaluated, and understanding the dynamics of bTB spread within…

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Universality classes of interaction structures for NK fitness landscapes

Kauffman's NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of L binary loci. The fitness assigned…

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Supplementation of Vitamin E protects chickens from Newcastle disease virus-mediated exacerbation of intestinal oxidative stress and tissue damage

Newcastle disease virus (NDV) causes a highly devastating and contagious disease in poultry, which is mainly attributed to extensive tissue damages in the digestive, respiratory and nervous systems. However, nature and dynamics of NDV-induced oxidative stresses in the…

At The Pirbright Institute Dr Mark Fife is committed to bee conservation

To bee, or not to bee? It’s not really a question for Dr Mark Fife, leader of the Genetics and Genomics group at The Pirbright Institute, who has installed two hives on site and whose honey bees (Apis mellifera) produced 42 pounds of honey in the first crop this summer…

Pirbright lead €5.6 million consortium to DEFEND against African swine fever and lumpy skin disease

African swine fever (ASF) and lumpy skin disease (LSD) represent an immediate and serious threat to the pig and cattle industries in Europe and eastern and central Asia. The need for a more collaborative approach to tackle these diseases has been recognised by the European…

nipah virus

Pirbright scientists are developing vaccine candidates for animal viruses that cause human disease

World Zoonoses Day on 6 July is dedicated to raising awareness and understanding of zoonoses – diseases that spread from animals to humans. Zoonoses are a focus of research at The Pirbright Institute, a national research centre that works to enhance the UK’s capability to…

Novel sampling method can detect foot-and-mouth disease in absence of clinical infection

Surveillance of livestock and their environment for the presence of FMDV is an important part of preventing outbreaks of foot-and-mouth disease (FMD), a disease which creates a socio-economic burden for the farming industry and smallholder or subsistence farmers alike…

Novel sampling method can detect foot-and-mouth disease in absence of clinical infection

Surveillance of livestock and their environment for the presence of FMDV is an important part of preventing outbreaks of foot-and-mouth disease (FMD), a disease which creates a socio-economic burden for the farming industry and smallholder or subsistence farmers alike…