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Empowering women worldwide

Thursday 8 March is a day to celebrate women’s social, economic, cultural and political achievements. International Women’s Day (IWD) has been formerly celebrated on 8 March since 1977, when the United Nations General Assembly invited member states to celebrate the day as…

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Macrophage colony stimulating factor increases hepatic macrophage content, liver growth and lipid accumulation in neonatal rats

Signaling via the colony stimulating factor 1 receptor (CSF1R) controls the survival, differentiation and proliferation of macrophages. Mutations in CSF1, or CSF1R in mice and rats have pleiotropic effects on postnatal somatic growth. We tested the possible application of…

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Recent advances in viral vectors in veterinary vaccinology

Viral vectored vaccines, particularly using vectors such as adenovirus, herpesvirus and poxviruses, are used widely in veterinary medicine, where this technology has been adopted much more quickly than in human medicine. There are now a large number of programmes to develop…

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Interaction of porcine monocyte-derived dendritic cells with African swine fever viruses of diverse virulence

African swine fever (ASF) is a devastating disease for which there is no vaccine. The ASF virus (ASFV) can infect dendritic cell (DC), but despite the critical role these cells play in induction of adaptive immunity, few studies investigated their response to ASFV infection…

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Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

In response to viral infection, cells mount a potent inflammatory response that relies on ISG15 and ubiquitin posttranslational modifications. Many viruses use deubiquitinases and deISGylases that reverse these modifications and antagonize host signaling processes. We here…

foot-and-mouth disease infected cell

Foot-and-mouth disease protein could be used for disease detection

Dr Stephen Berryman and Dr Toby Tuthill from The Pirbright Institute have collaborated with the MRC Laboratory of Molecular Biology and other research institutes* to uncover a new system used by the foot-and-mouth disease virus (FMDV) to prevent antiviral signalling of…

Cells infected with African swine fever

Advance in the hunt for African swine fever vaccine

Researchers from The Pirbright Institute have made a promising step forward by identifying key African swine fever virus (ASFV) proteins that induce immune responses in pigs. ASFV is an extremely severe and economically important disease of domestic pigs, which is usually…

Foot-and-mouth disease

Diagnosis of foot-and-mouth disease (FMD): Instructor-led

Learn FMDV isolation, detection, genome analysis, and vaccine matching.

Scientist at bench

Transboundary diseases: Instructor-led

Learn quality management, virus isolation, ELISA, and PCR techniques.

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The application of NHEJ-CRISPR/Cas9 and Cre-Lox system in the generation of bivalent duck enteritis virus vaccine against avian influenza virus

Duck-targeted vaccines to protect against avian influenza are critically needed to aid in influenza disease control efforts in regions where ducks are endemic for highly pathogenic avian influenza (HPAI). Duck enteritis virus (DEV) is a promising candidate viral vector for…