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Pirbright research to tackle Asian viruses

The Pirbright Institute has been awarded over £1million by the BBSRC-Newton Fund to tackle four major viral diseases that threaten livestock populations across Asia. Pirbright scientists will study two poultry and two pig diseases that have a severe impact on the wellbeing…

Marek's disease virus vaccine

New vaccine technique targets multiple poultry diseases

Researchers at The Pirbright Institute have created a new method of genetically modifying the Marek’s disease vaccine so that it is able to protect against another destructive poultry virus called infectious bursal disease (IBD), and potentially others such as avian…

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Development and optimization of a differentiated airway epithelial cell model of the bovine respiratory tract

Cattle are subject to economically-important respiratory tract infections by various bacterial and viral pathogens and there is an urgent need for the development of more realistic in vitro models of the bovine respiratory tract to improve our knowledge of disease…

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Trypanosoma rhipicephalis sp. nov. (Protozoa: Kinetoplastida) isolated from Rhipicephalus microplus (Acari: Ixodidae) ticks in Rio de Janeiro, Brazil

Parasites of the genus Trypanosoma are unicellular flagellated microorganisms of the Trypanosomatidae. This study describes an isolate of the genus Trypanosoma naturally infecting Rhipicephalus microplus ticks, characterized through molecular, morphological and biological…

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Antiviral effect of lithium chloride on replication of avian leukosis virus subgroup J in cell culture

Lithium chloride (LiCl) has been reported to possess antiviral activity against several viruses. In the current study, we assessed the antiviral activity effect of LiCl on ALV-J infection in CEF cells by using real-time PCR, Western blot analysis, IFA and p27 ELISA analysis…

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Implementation of tissue histopathology and parasitic morphometric analysis in the diagnosis of Myxobolus fomenai infection in the skeletal muscles Nile tilapia

Class Myxosporea includes Myxobolus parasite. Myxosporean species could infect the skeletal muscles of freshwater fish, including Nile tilapia. In this study, four Nile tilapia fish, collected from a fish farm in Dakahleya province, died and showed gross lesions of…

Pirbright gains funding to tackle lumpy skin disease

The Pirbright Institute’s Dr Pip Beard has been awarded funding to study lumpy skin disease (LSD), a severe viral disease of cattle which is found throughout Africa and the Middle East. Little is known about the LSD virus, so the award will be used to answer fundamental…

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Detection of pathogen exposure in African buffalo using non-specific markers of inflammation

Detecting exposure to new or emerging pathogens is a critical challenge to protecting human, domestic animal and wildlife health. Yet current techniques to detect infections typically target known pathogens of humans or economically important animals. In the face of the…

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The third moments of the site frequency spectrum

The analysis of patterns of segregating (i.e. polymorphic) sites in aligned sequences is routine in population genetics. Quantities of interest include the total number of segregating sites and the number of sites with mutations of different frequencies, the so-called site…