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Prior Puma lentivirus infection modifies early immune responses and attenuates feline immunodeficiency virus infection in cats

We previously showed that cats that were infected with non-pathogenic Puma lentivirus (PLV) and then infected with pathogenic feline immunodeficiency virus (FIV) (co-infection with the host adapted/pathogenic virus) had delayed FIV proviral and RNA viral loads in blood, with…

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A traditional evolutionary history of foot-and-mouth disease viruses in Southeast Asia challenged by analyses of non-structural protein coding sequences

Recombination of rapidly evolving RNA-viruses provides an important mechanism for diversification, spread, and emergence of new variants with enhanced fitness. Foot-and-mouth disease virus (FMDV) causes an important transboundary disease of livestock that is endemic to most…

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Within-host recombination in the foot-and-mouth disease virus genome

Recombination is one of the determinants of genetic diversity in the foot-and-mouth disease virus (FMDV). FMDV sequences have a mosaic structure caused by extensive intra- and inter-serotype recombination, with the exception of the capsid-encoding region. While these genome…

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The MHC homozygous inbred Babraham pig as a resource for veterinary and translational medicine

The Babraham pig is a highly inbred breed first developed in the United Kingdom approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the MHC region, but confirmation of homozygosity at the specific MHC loci was…

Brown goat

Tackling sheep and goat pox in Nigeria

Researchers from The Pirbright Institute recently journeyed to Nigeria as part of their collaboration with Bauchi State College of Agriculture, which focuses on understanding sheeppox and goatpox in order to reduce their impact in low and middle income countries. Goat…

The Houghton Facility

A facility to hatch and raise poultry under sterile conditions.

BBSRC National Vaccinology Centre: The Jenner Building

The BBSRC National Vaccinology Centre: The Jenner Building

A state-of-the-art low-containment facility supporting vital research on endemic poultry and livestock viruses, immunology, and genomics.

Gene editing

Pirbright research to boost vaccine production

Scientists at The Pirbright Institute have received money which will enable research into boosting vaccine yields by up to ten fold. The funding was awarded by the Livestock Vaccine Innovation Fund which is supported by the Bill & Melinda Gates Foundation (BMGF), Global…

Plowright Building

The BBSRC National Virology Centre: The Plowright Building

A state-of-the-art, high containment laboratory for researching high-risk, exotic and zoonotic viruses.

The Plowright Building

Facilities and resources

Explore our specialist science facilities, cutting-edge technology platforms, and request services like diagnostic testing.