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Predicting airway immune responses and protection from immune parameters in blood following immunization in a pig influenza model

Whereas the intranasally delivered influenza vaccines used in children affect transmission of influenza virus in the community as well as reducing illness, inactivated influenza vaccines administered by intramuscular injection do not prevent transmission and have a variable…

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Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in Kenya

Increased immune evasion by emerging and highly mutated SARS-CoV-2 variants is a key challenge to the control of COVID-19. The majority of these mutations mainly target the spike protein, allowing the new variants to escape the immunity previously raised by vaccination and…

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The pseudoknot region and poly-(C) tract comprise an essential RNA packaging signal for assembly of foot-and-mouth disease virus

Virus assembly is a crucial step for the completion of the viral replication cycle. In addition to ensuring efficient incorporation of viral genomes into nascent virions, high specificity is required to prevent incorporation of host nucleic acids. For picornaviruses…

Single large pink pig standing on hay looking at the camera

Pig research paves way for human respiratory vaccine development

A study in pigs, which shows that inhaled vaccines could potentially reduce viral transmission and improve efficiency, is an important step toward advancing vaccines for human use. Interest in administering vaccines mucosally, rather than by intramuscular injections, has…

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No evidence that mutations in SARS-CoV-2 variants of concern derive from homologous fragments in gut microbiota

Understanding the origin and evolution of mutations in SARS-CoV-2 variants of concern (VOCs) is a critical area of research. B. Cao, X. Wang, W. Yin, Z. Gao, and B. Xia (mBio 15:e03187-23, 2024, https://doi.org/10.1128/mbio.03187-23) proposed that these mutations originated…

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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes

African swine fever virus (ASFV) is a high-consequence pathogen posing a substantial threat to global food security. This large DNA virus encodes more than 150 open reading frames, many of which are uncharacterized. The EP402R gene encodes CD2v, a glycoprotein expressed on…

Image shows dog heart tissue infected with foot-and-mouth disease virus (FMDV). Green and red show FMDV proteins, blue shows cell nuclei.

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Viral miRNA delivered by exosomes from Marek's disease virus-transformed lymphoma cell line exerts regulatory function in internalized primary chicken embryo fibroblast cells

In the past decade, research has demonstrated that viral miRNAs encoded by a number of viral genomes, particularly by most of the herpesvirus including Marek's disease virus (MDV), play important regulatory roles in viral infection, replication, and regulation of…

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Clinical disease in British sheep infected with an emerging strain of bluetongue virus serotype 3

Background Bluetongue virus serotype 3 (BTV-3) was detected for the first time in cattle and sheep in southern England in 2023, the first UK BTV incursion for more than 15 years. Clinical signs were not observed, yet severe clinical disease and mortality were reported during…

Research offers hope for future African swine fever vaccine

Scientists have gained new insights into African swine fever virus (ASFV), a deadly pathogen that causes major losses in global pig farming and threatens global food security. A study, led by The Pirbright Institute and published today in mBio, uses a novel strategy to make…