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Marek's disease virus-encoded microRNA-M6-5p facilitates viral latent infection by targeting histone demethylase KDM2B

Marek's disease virus (MDV), a highly contagious and oncogenic avian alphaherpesvirus, establishes a latent infection primarily in CD4 + T cells. Latent infections are necessary for both persistent lifelong MDV infection and viral tumorigenesis. MicroRNAs (miRNAs) play…

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FABP4 as a therapeutic host target controlling SARS-CoV-2 infection

Host metabolic fitness is a critical determinant of infectious disease outcomes. Obesity, aging, and other related metabolic disorders are recognized as high-risk disease modifiers for respiratory infections, including coronavirus infections, though the underlying mechanisms…

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Detection and genomic characterisation of foot-and-mouth disease virus serotypes circulating in Cameroon using environmental sampling

Foot-and-mouth disease virus (FMDV) is a highly contagious, economically important disease of livestock and wildlife species. Active monitoring and understanding the epidemiology of FMDV underpin the foundations of control programmes. In many endemic areas, however…

Two mosquitoes laid out facing each other

Insect transgenesis

Generating genetically modified insects to uncover virus-vector interactions.

Close up of pink pig face snoozing on straw

Pirbright’s pig immunology expertise advances cystic fibrosis research

A pig model is enhancing cystic fibrosis research.

Flock of white sheep on grass. A long line of them extends into the background down a slope

Pirbright shares award to make affordable anti-parasite vaccine

Scientists at the Moredun Research Institute, near Edinburgh, and The Pirbright Institute have been awarded a £1.7 million grant over three years by the Bill & Melinda Gates Foundation to develop a vaccine against a life-threatening parasite of sheep and goats. The parasite…

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The pseudoknot region and poly-(C) tract comprise an essential RNA packaging signal for assembly of foot-and-mouth disease virus

Virus assembly is a crucial step for the completion of the viral replication cycle. In addition to ensuring efficient incorporation of viral genomes into nascent virions, high specificity is required to prevent incorporation of host nucleic acids. For picornaviruses…

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GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

The Eurasian avian-like (EA) H1N1 swine influenza virus (SIV) possesses the capacity to instigate the next influenza pandemic, owing to its heightened affinity for the human-type α-2,6 sialic acid (SA) receptor. Nevertheless, the molecular mechanisms underlying the switch in…

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An evaluation of financial losses due to lumpy skin disease outbreaks in dairy farms of Northern Thailand

Lumpy skin disease (LSD) poses a significant threat to the cattle industry, resulting in adverse economic consequences in affected countries. This study aims to estimate the financial losses economic impact due to LSD outbreaks in dairy farms in northern Thailand. Based on a…

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Serological Cross-reactivity between Crimean-Congo Haemorrhagic Fever Virus (CCHFV) and Nairobi Sheep Disease Virus (NSDV) glycoprotein C (Gc)

Cross-reactivity to viruses of the Orthonairovirus genus can potentially interfere with serological assays when employed for serosurveillance in regions where two or more genus members overlap in their distribution. To investigate this, Crimean-Congo haemorrhagic fever virus…