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Using the basic reproduction ratio to quantify transmission and identify data gaps for epizootic haemorrhagic disease virus

Epizootic haemorrhagic disease virus (EHDV) is an arbovirus transmitted by Culicoides biting midges that has recently emerged in Europe. Here, the basic reproduction ratio (R0) was used to quantify the transmission of EHDV and its dependence on temperature for cattle and…

Pig sniffing at apple

Outbred pigs can serve as model for human therapeutics

Laboratory-made monoclonal antibodies are used to treat conditions including cancer, autoimmune and infectious diseases. Commercial outbred pigs can be used as models to test how quickly therapeutic monoclonal antibodies (mAbs) disappear from the human body after injection…

Emerging threat: Study reveals gaps in knowledge about EHDV transmission in Europe

A new study highlights significant gaps in our understanding of the transmission dynamics of epizootic haemorrhagic disease virus (EHDV) which primarily infects cattle and deer. EHDV was detected in Europe for the first time in 2022, with outbreaks reported in Italy and…

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Activation of the mitochondrial unfolded protein response regulates the dynamic formation of stress granules

To rapidly adapt to harmful changes to their environment, cells activate the integrated stress response (ISR). This results in an adaptive transcriptional and translational rewiring, and the formation of biomolecular condensates named stress granules (SGs), to resolve stress…

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Assessment of PPMV-1 Genotype VI Virulence in Pigeons and Chickens and Protective Effectiveness of Paramyxovirus Vaccines in Pigeons

Pigeon paramyxovirus serotype 1 (PPMV-1), an antigenic and host variant of avian paramyxovirus Newcastle disease virus (NDV), primarily originating from racing pigeons, has become a global panzootic. Egypt uses both inactivated PPMV-1 and conventional NDV vaccines to protect…

Three photos of Munir, Don and Georgina at lecterns presenting

Pirbright expertise supporting control of livestock diseases in North Africa

Three scientists from The Pirbright Institute have shared their knowledge of tackling animal viruses at a North African conference. Professor Munir Iqbal, Dr Donald King and Dr Georgina Limon-Vega addressed an audience of vets and representatives from animal health…

Three photos of Munir, Don and Georgina at lecterns presenting

Pirbright expertise supporting control of livestock diseases in North Africa

Three scientists from The Pirbright Institute have shared their knowledge of tackling animal viruses at a North African conference. Professor Munir Iqbal, Dr Donald King and Dr Georgina Limon-Vega addressed an audience of vets and representatives from animal health…

Three photos of Munir, Don and Georgina at lecterns presenting

Pirbright expertise supporting control of livestock diseases in North Africa

Three scientists from The Pirbright Institute have shared their knowledge of tackling animal viruses at a North African conference. Professor Munir Iqbal, Dr Donald King and Dr Georgina Limon-Vega addressed an audience of vets and representatives from animal health…

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A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation

The inbred Babraham pig serves as a valuable biomedical model for research due to its high level of homozygosity, including in the major histocompatibility complex (MHC) loci and likely other important immune-related gene complexes, which are generally highly diverse in…

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The 2024 IPD-MHC database update: a comprehensive resource for major histocompatibility complex studies

The IPD-MHC Database project (http://www.ebi.ac.uk/ipd/mhc/) serves as a comprehensive and expertly curated repository for major histocompatibility complex (MHC) sequences from non-human species, providing the necessary infrastructure and tools to study the function and…