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High pathogenicity avian influenza H5N5: the next threat?

Linda, Alison and Louise. Linda is stood behind Alison and Louise with gold balloons 4 and 0 while Alison and Louise are sat. Alison on the left holds a gold 2 balloon while Louise holds a gold 5 balloon.

Three dedicated staff celebrate Long Service Awards

Three dedicated colleagues who have worked at The Pirbright Institute for a combined total of 90 years are celebrating Long Service Awards. Group leader Dr Linda Dixon has served 40 years, whilst researcher Dr Alison Burman and animal services specialist Louise Stevenson are…

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Activation of the mitochondrial unfolded protein response regulates the dynamic formation of stress granules

To rapidly adapt to harmful changes to their environment, cells activate the integrated stress response (ISR). This results in an adaptive transcriptional and translational rewiring, and the formation of biomolecular condensates named stress granules (SGs), to resolve stress…

Artist impression of CVIM building

CVIM to accelerate global vaccine development

The Pirbright Institute is partnering with Scitech, a leading specialist in pharmaceutical design, engineering, construction and qualification, to build and deliver a new Centre for Veterinary Vaccine Innovation and Manufacturing (CVIM). CVIM’s mission is to fulfil an unmet…

Aerial shot of The Brooksby Building surrounded by woodland and The Pirbright Institute site

Major new facility supports pandemic preparedness

A major new high-biological containment science facility, to be named The Brooksby Building, has been completed by The Pirbright Institute. Pirbright is the UK’s world-leading centre of excellence in research and surveillance of viral diseases of livestock, and viruses that…

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Genetic coping mechanisms observed in Leishmania tropica, from the Middle East region, enhance the survival of the parasite after drug exposure

Introduction: Cutaneous leishmaniasis caused by L. tropica is common in the Middle East and treatment failure and drug resistance are known to occur. Several genetic mechanisms: aneuploidy, recombination and loss of heterozygosity, single nucleotide polymorphism (SNP)…

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Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves

Parthanatos is distinct from caspase-dependent apoptosis in that it does not necessitate the activation of caspase cascades; Instead, it relies on the translocation of Apoptosis-inducing Factor (AIF) from the mitochondria to the nucleus, resulting in nuclear DNA…

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Antimicrobial resistance genes and associated mobile genetic elements in Escherichia coli from human, animal and environment

The global rise of antimicrobial resistance (AMR) poses a significant threat to human health. The environment plays an essential role in transmission of antimicrobial resistance genes (ARGs) between human and animal. Bacterial communities harbour diverse ARGs, carried by…

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Coxsackievirus A6 U.K. Genetic and Clinical Epidemiology Pre- and Post-SARS-CoV-2 Emergence

Coxsackievirus A6 (CVA6) has become increasingly clinically relevant as a cause of Hand, Foot and Mouth Disease (HFMD) globally since 2008. However, most laboratories do not routinely determine the enteroviral type of positive samples. The non-pharmaceutical measures…

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Non-typhoidal Salmonella in humans in India, Vietnam, Bangladesh and Sri Lanka: a systematic review

Objectives: Non-typhoidal Salmonella (NTS) commonly causes a self-limiting illness but invasive disease (iNTS) can be life-threatening. Antimicrobial resistance (AMR) increases the risk of mortality. This systematic review aimed to estimate the proportion of NTS isolated in…