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Development and evaluation of a nested PCR for improved diagnosis and genetic analysis of peste des petits ruminants virus (PPRV) for future use in nascent PPR eradication programme

Peste des petits ruminants (PPR) is a highly contagious viral disease of small ruminants caused by PPR virus (PPRV). PPR is endemic in Asia, the Middle East and across large areas of Africa and is currently targeted for global eradication by 2030. The virus exists as four…

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Respiratory and intramuscular immunization with ChAdOx2-NPM1-NA induces distinct immune responses in H1N1pdm09 pre-exposed pigs

There is a critical need to develop superior influenza vaccines that provide broader protection. Influenza vaccines are traditionally tested in naive animals, although humans are exposed to influenza in the first years of their lives, but the impact of prior influenza…

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Simultaneous infection with porcine reproductive and respiratory syndrome and influenza viruses abrogates clinical protection induced by live attenuated porcine reproductive and respiratory syndrome vaccination

The porcine respiratory disease complex (PRDC) is responsible for significant economic losses in the pig industry worldwide. Porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus are major viral contributors to PRDC. Vaccines are cost…

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Antiviral effect of lithium chloride on replication of Marek's disease virus in chicken embryonic fibroblasts

To investigate the antiviral effect of lithium chloride (LiCl) on the replication of Marek's disease virus (MDV) in chicken embryonic fibroblast (CEF) cells, real-time PCR, Western blotting, plaque counting, and indirect immunofluorescence experiments were performed at…

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Access and benefit-sharing by the European Virus Archive in response to COVID-19

The ongoing COVID-19 pandemic has emphasized the importance of global collaboration and our reliance on fast and efficient sharing of pathogen genetic resources (PGR). Biobanking infrastructures are critical early responders to new viral outbreaks that share PGR in an…

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Exchange of C-terminal variable sequences within morbillivirus nucleocapsid protein are tolerated: development and evaluation of two marker (DIVA) vaccines (Sungri/96 DIVA, Nigeria/75/1 DIVA) against PPR

Across Africa, the Middle East, and Asia, peste des petits ruminants virus (PPRV) places a huge disease burden on agriculture, affecting, in particular, small ruminant production. The recent PPR outbreaks in Northern Africa, the European part of Turkey, and Bulgaria…

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Pirbright student wins Social Impact Award for COVID-19 work in Romania and UK

The COVID-19 pandemic has had a devastating impact on public health and the global economy. Vaccine rollouts, ongoing global research and test and trace programmes each play a crucial role in tackling the virus but so does increasing public knowledge and confidence in each…

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Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines

BACKGROUND: A commensal microbiota regulates and is in turn regulated by viruses during host infection which can influence virus infectivity. In this study, analysis of colon microbiota population changes following a low pathogenicity avian influenza virus (AIV) of the H9N2…

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Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

The limited knowledge on the role of many of the approximately 170 proteins encoded by African swine fever virus restricts progress toward vaccine development. Previously, the DP148R gene was deleted from the genome of genotype I virulent Benin 97/1 isolate. This virus…