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Identification and characterization of a novel epitope of ASFV-encoded dUTPase by monoclonal antibodies

Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) of African swine fever virus (ASFV) is an essential enzyme required for efficient virus replication. Previous crystallography data have indicated that dUTPase (E165R) may serve as a therapeutic target for inhibiting…

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A deeper insight on evolutionary patterns and phylogenetic history of ASFV epidemics in Sardinia (Italy) through extensive genomic sequencing.

African swine fever virus (ASFV) is the etiological agent of the devastating disease African swine fever (ASF), for which there is currently no licensed vaccine or treatment available. ASF is defined as one of the most serious animal diseases identified to date, due to its…

A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles are coloured red, the rest of the cell image is purple.

Zika virus

Zika virus (ZIKV) is primarily transmitted by mosquitoes in tropical and subtropical regions.

A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles are coloured red, the rest of the cell image is purple.

Zika virus

Zika virus (ZIKV) is primarily transmitted by mosquitoes in tropical and subtropical regions.

Dengue virus electron microscopy image

Dengue virus

Dengue virus (DENV), present predominantly in tropical regions, is primarily transmitted to humans by infected mosquitoes.

Dengue virus electron microscopy image

Dengue virus

Dengue virus (DENV), present predominantly in tropical regions, is primarily transmitted to humans by infected mosquitoes.

Glass model of foot-and-mouth-disease virus (FMDV), lit in purple

Pirbright welcomes three scientific experts to head up new areas of research

Three new research groups have been established at The Pirbright Institute recently, each of which will contribute to the Institute’s mission to prevent and control viral diseases of livestock and viruses that spread from animals to people, known as zoonoses. Discover more…

Glass model of foot-and-mouth-disease virus (FMDV), lit in purple

Pirbright welcomes three scientific experts to head up new areas of research

Three new research groups have been established at The Pirbright Institute recently, each of which will contribute to the Institute’s mission to prevent and control viral diseases of livestock and viruses that spread from animals to people, known as zoonoses. Discover more…

Glass model of foot-and-mouth-disease virus (FMDV), lit in purple

Pirbright welcomes three scientific experts to head up new areas of research

Three new research groups have been established at The Pirbright Institute recently, each of which will contribute to the Institute’s mission to prevent and control viral diseases of livestock and viruses that spread from animals to people, known as zoonoses. Discover more…

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The flavivirus polymerase NS5 regulates translation of viral genomic RNA

Flaviviruses, including dengue virus and Zika virus, contain a single-stranded positive sense RNA genome that encodes viral proteins essential for replication and also serves as the template for new genome synthesis. As these processes move in opposite directions along the…