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Research paper

Advances in control techniques for Culicoides and future prospects

In most instances, vaccination is accepted to be the most effective method of preventing Culicoides-borne arbovirus transmission, as it has proven to be successful in large-scale campaigns. Under certain scenarios, however, vaccines require time to be developed and deployed…
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Research paper

Distribution and load of elephant endotheliotropic herpesviruses in tissues from associated fatalities of Asian elephants

Elephant Endotheliotropic Herpesviruses (EEHVs) are the cause of a highly fatal haemorrhagic disease in elephants primarily affecting young Asian elephants (Elephas maximus) in both captivity and in the wild. The viruses have emerged as a significant threat to Asian elephant…
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Research paper

Bioinformatics and molecular analysis of the evolutionary relationship between bovine rhinitis A viruses and foot-and-mouth disease virus

Bovine rhinitis viruses (BRVs) cause mild respiratory disease of cattle. In this study, a near full-length genome sequence of a virus named RS3X (formerly classified as bovine rhinovirus type 1), isolated from infected cattle from the UK in the 1960s, was obtained and…
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Research paper

The pathology and pathogenesis of bluetongue

Bluetongue (BT) is an insect-transmitted viral disease of wild and domestic ruminants and, occasionally, other species. Amongst domestic livestock, BT is most common in certain breeds of sheep whereas asymptomatic BT virus (BTV) infection of cattle is typical in enzootic…
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Research paper

Comparison of cellular and humoral immunoassays for the assessment of summer eczema in horses

The objective of this study was to compare and analyze three common diagnostic methods for summer eczema (SE) in horses, an allergic dermatitis caused by bites of Culicoides spp. Nine horses with a medical history of SE and nine control animals were intradermally challenged…
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Research paper

Differential diagnosis of bluetongue in cattle and sheep

In 2006, bluetongue virus serotype 8 (BTV-8) caused the first recorded bluetongue outbreak in northern Europe. This occurred in countries with no previous history of bluetongue virus incursion, including the Netherlands, Belgium and Germany. Following a halt to disease…
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Research paper

A duplex RT-PCR assay for detection of genome segment 7 (VP7 gene) from 24 BTV serotypes

Since 1998, six distinct serotypes of Bluetongue virus (BTV) have invaded Southern and Central Europe, persisting in some regions for up to 6 years and resulting in the deaths of >1.8 million sheep. Rapid and reliable methods of virus detection and identification play an…
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Research paper

Collection and analysis of salivary proteins from the biting midge Culicoides nubeculosus (Diptera: Ceratopogonidae)

Salivary proteins of hematophagous Culicoides spp. are thought to play an important role in pathogen transmission and skin hypersensitivity. Analysis of these proteins, however, has been problematic due to the difficulty in obtaining adequate amounts of secreted Culicoides…
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Article

Maintaining global freedom from rinderpest

The 3rd International Meeting on ‘Maintaining Global Freedom from Rinderpest’ was held in Kathmandu, Nepal on 14-16 June 2017. The meeting brought together a global audience, including a group of scientists from The Pirbright Institute, who discussed plans for controlling…
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Article

World Zoonoses Day: New study highlights how Pirbright research helps protect animals and humans

An international research collaboration exploring new ways to control influenza viruses led by The Pirbright Institute has provided insights that could lead to the design of better vaccines for animals and humans. Pirbright scientists are highlighting this research today -…
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