Search | The Pirbright Institute

Filters

default publication image

Evolutionary insights into the fusion protein of Newcastle disease virus isolated from vaccinated chickens in 2016 in Egypt

Newcastle disease virus (NDV) infections are one of the most devastating causes of economic losses in the poultry industry and despite extensive vaccination, outbreaks are being reported around the globe especially from developing and tropical countries. Analysis of NDV…

default publication image

Subset-specific expression of toll-like receptors by bovine afferent lymph dendritic cells

Within the ruminant system, several possibilities exist to generate dendritic cells migrating out from the tissue into the regional draining lymphnodes as afferent lymph dendritic cells (ALDC). Here, we analysed Toll-like receptor (TLR) 110 mRNA expression by using…

Pirbright’s National Vaccinology Centre finalist at Construction News Awards

Staff and scientists at The Pirbright Institute are proud today following the Construction News Awards, where John Sisk & Son were finalists in the Project of the Year category for their work on the BBSRC National Vaccinology Centre: The Jenner Building - located at the…

Sequential vaccination identifies immune cells against multiple FMD serotypes

Researchers at The Pirbright Institute have shown for the first time that vaccinating cattle at intervals with different types of foot-and-mouth disease virus (FMDV) can identify immune cells which recognise shared structures across FMDV types. There are seven different…

default publication image

Exploiting serological data to understand the epidemiology of foot-and-mouth disease virus serotypes circulating in Libya

Sporadic outbreaks of foot-and-mouth disease (FMD) have occurred in Libya for almost fifty years. During the spring of 2013, a countrywide serosurvey was undertaken to assess the level of FMD virus circulation and identify FMD virus serotypes in the country. A total of 4221…

default publication image

The B cell response to foot-and-mouth disease virus in cattle following sequential vaccination with multiple serotypes

Foot-and-mouth disease virus (FMDV) is a highly contagious viral disease. Antibodies are pivotal in providing protection against FMDV infection. Serological protection against one FMDV serotype does not confer interserotype protection. However, some historical data have…

default publication image

The B cell response to foot-and-mouth disease virus in cattle following sequential vaccination with multiple serotypes

Foot-and-mouth disease virus (FMDV) is a highly contagious viral disease. Antibodies are pivotal in providing protection against FMDV infection. Serological protection against one FMDV serotype does not confer interserotype protection. However, some historical data have…

default publication image

Affimer proteins are versatile and renewable affinity reagents

Molecular recognition reagents are key tools for understanding biological processes and are used universally by scientists to study protein expression, localisation and interactions. Antibodies remain the most widely used of such reagents and many show excellent performance…

default publication image

Determining phenological patterns associated with the onset of senescence in a wheat MAGIC mapping population

The appropriate timing of developmental transitions is critical for adapting many crops to their local climatic conditions. Therefore, understanding the genetic basis of different aspects of phenology could be useful in highlighting mechanisms underpinning adaptation, with…

default publication image

Surviving and fatal Elephant Endotheliotropic Herpesvirus-1A infections in juvenile Asian elephants - lessons learned and recommendations on anti-herpesviral therapy

Background: Elephant Endotheliotropic Herpesviruses (EEHVs) can cause acute haemorrhagic disease in young Asian elephants (Elephas maximus) and clinical EEHV infections account for the majority of their fatalities. The anti-herpesviral drug famciclovir (FCV) has been used…