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Basic page Non-vesicular disease diagnostic testing Testing for African horse sickness, African swine fever, bluetongue, Capripox (sheep pox, goat pox and lumpy skin disease), epizootic haemorrhagic disease, and peste des petits ruminants. Read more
Article Pirbright awarded £2,359,553 grant for vaccine work on Nipah virus A £2,359,553 grant has been awarded by Innovate UK to The Pirbright Institute’s Dr Simon Graham to lead an international team developing an inexpensive, safe and effective vaccine to protect pigs against Nipah virus (NiV). The grant will allow scientists from Pirbright and… Read more
Research paper Global distributions and strain diversity of avian infectious bronchitis virus: a review The poultry industry faces challenge amidst global food security crisis. Infectious bronchitis is one of the most important viral infections that cause huge economic loss to the poultry industry worldwide. The causative agent, infectious bronchitis virus (IBV) is an RNA… Read more
Research paper Assessing evidence for avian-to-human transmission of influenza A/H9N2 virus in rural farming communities in northern Vietnam Rural farming communities in northern Vietnam do not routinely practice vaccination for influenza A viruses (IAV) for either humans or poultry, which enables us to study transmission intensity via seroepidemiology. Using samples from a longitudinal cohort of farming… Read more
Research paper Mast cells and innate immunity: master troupes of the avian immune system Mast cells (MCs) are granulated cells of haematopoietic lineage and constitute a major sensory arm of the immune system. MCs dually guard hosts and regulate immune responses against invading pathogens. This property of the MCs is attributed to their adaptability to detect… Read more
Research paper Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB Toll-like receptor-3 (TLR3), a member of the pathogen recognition receptor family, has been reported to activate immune response and to exhibit pro-apoptotic activity against some tumor cells. However it is unclear whether TLR3 has same function against chicken lymphoma. In… Read more
Article Field test first to type FMD outside of the lab Scientists at The Pirbright Institute have successfully validated two new portable tests for the diagnosis of foot-and-mouth disease (FMD). One test confirms the presence of FMD virus (FMDV), and the other is the first portable test able to differentiate between the four FMD… Read more
Research paper Properties of the tick-borne encephalitis virus population during persistent infection of ixodid ticks and tick cell lines Tick-borne encephalitis virus (TBEV) is the causative agent of tick-borne encephalitis (TBE), a vector-borne zoonotic neuroinfection. For successful circulation in natural foci the virus has to survive in the vector for a long period of time. Information about the effect of… Read more
Research paper Ex vivo PD-L1/PD-1 pathway blockade reverses dysfunction of circulating CEA specific T cells in pancreatic cancer patients Carcinoembryonic antigen (CEA) is a candidate target for cellular immunotherapy of pancreatic cancer (PC). In this study, we have characterised the antigen-specific function of autologous cytotoxic T lymphocytes (CTL) specific for the HLA-A2 restricted peptide, pCEA691-699… Read more
