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Measles epidemics in Romania: lessons for public health and future policy

Measles is a highly infectious viral disease that continues to be a challenge for many countries worldwide. Although significant improvements have been observed since the introduction of vaccines, measles remains endemic in Romania. Contributing factors include vaccine…

african buffalo - needs credit: Haplochromis [CC BY-SA 3.0 (httpscreativecommons.orglicensesby-sa3.0)]

Persistently infected African buffalo not a likely cause of new FMD outbreaks say Pirbright scientists

Scientists at The Pirbright Institute have shown that African buffalo persistently infected with foot-and-mouth disease (FMD) are unlikely to be the source of new outbreaks in other buffalo and cattle. African buffalo do not usually present any clinical signs of infection…

Pig head tongue pirbright

Pirbright and ViroVet join forces to develop African swine fever antivirals

Researchers at The Pirbright Institute will partner with the Belgian biotechnology company ViroVet to develop the first antiviral drugs that act against African swine fever (ASF). In the absence of a vaccine, antiviral drugs could provide an alternative control method which…

bbsrc innovator of the year awards dr andrew broadbent and dr amin asfor

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Two scientists from The Pirbright Institute attended the BBSRC Innovator of the Year Awards on 15 May 2019 as shortlisted finalists. Dr Andrew Broadbent and Dr Amin Asfor pitched their research against ten other scientists and groups across four categories: Commercial Impact…

Eggs

Pirbright scientists identify mutation hotspots that may inform infectious bronchitis vaccine development

Scientists at The Pirbright Institute have shown that infectious bronchitis virus (IBV) vaccines produced in eggs have unpredictable mutations which may be prone to reversion in the field. IBV causes a poultry disease which results in large economic losses across the globe…

Eggs

Pirbright scientists identify mutation hotspots that may inform infectious bronchitis vaccine development

Scientists at The Pirbright Institute have shown that infectious bronchitis virus (IBV) vaccines produced in eggs have unpredictable mutations which may be prone to reversion in the field. IBV causes a poultry disease which results in large economic losses across the globe…

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Comparative analysis of the chicken IFITM locus by targeted genome sequencing reveals evolution of the locus and positive selection in IFITM1 and IFITM3

The interferon-induced transmembrane (IFITM) protein family comprises a class of restriction factors widely characterised in humans for their potent antiviral activity. Their biological activity is well documented in several animal species, but their genetic variation and…

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Sequential disruption of ALV host receptor genes reveals no sharing of receptors between ALV subgroups A, B, and J

Previously, we showed that targeted disruption of viral receptor genes in avian leukosis virus (ALV) subgroups using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9))-based genome editing confers resistance to ALV…

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The evolution and phylodynamics of serotype A and SAT2 foot-and-mouth disease viruses in endemic regions of Africa

Foot-and-mouth disease (FMD) is a major livestock disease with direct clinical impacts as well as indirect trade implications. Control through vaccination and stamping-out has successfully reduced or eradicated the disease from Europe and large parts of South America…

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Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus

Swine influenza A virus (SwIV) infection has considerable economic and animal welfare consequences and, because of the zoonotic potential, can also have public health implications. The 2009 pandemic H1N1 ‘swine-origin’ infection is now endemic in both pigs and humans. In…