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Targeted editing of the pp38 gene in Marek's disease virus-transformed cell lines using CRISPR/Cas9 system

Marek's disease virus (MDV), a lymphotropic alpha-herpesvirus associated with T-cell lymphomas in chickens, is an excellent model for herpesvirus biology and virus-induced oncogenesis. Marek's disease (MD) is also one of the cancers against which a vaccine was first used. In…

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The genetics of life and death: virus-host interactions underpinning resistance to African swine fever, a viral haemorrhagic disease

Pathogen transmission from wildlife hosts to genetically distinct species is a major driver of disease emergence. African swine fever virus (ASFV) persists in sub-Saharan Africa through a sylvatic cycle between warthogs and soft ticks that infest their burrows. The virus…

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Identification of novel epitopes in serotype O foot-and-mouth disease virus by in vitro immune selection

Foot-and-mouth disease virus (FMDV) displays various epitopes on the capsid outer surface. In addition to the five neutralizing antigenic sites, there is evidence of the existence of other, yet unidentified, epitopes that are believed to play a role in antibody-mediated…

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Using the basic reproduction number to assess the risk of transmission of lumpy skin disease virus by biting insects

In recent years, lumpy skin disease virus (LSDV) has emerged as a major threat to cattle outside Africa, where it is endemic. Although evidence suggests that LSDV is transmitted by the bites of blood sucking arthropods, few studies have assessed the risk of transmission…

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African swine fever virus evasion of host defences

African swine fever virus causes a haemorrhagic fever in domestic pigs and wild boar. The continuing spread in Africa, Europe and Asia threatens the global pig industry. The lack of a vaccine limits disease control. To underpin rational strategies for vaccine development…

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Measles epidemics in Romania: lessons for public health and future policy

Measles is a highly infectious viral disease that continues to be a challenge for many countries worldwide. Although significant improvements have been observed since the introduction of vaccines, measles remains endemic in Romania. Contributing factors include vaccine…

african buffalo - needs credit: Haplochromis [CC BY-SA 3.0 (httpscreativecommons.orglicensesby-sa3.0)]

Persistently infected African buffalo not a likely cause of new FMD outbreaks say Pirbright scientists

Scientists at The Pirbright Institute have shown that African buffalo persistently infected with foot-and-mouth disease (FMD) are unlikely to be the source of new outbreaks in other buffalo and cattle. African buffalo do not usually present any clinical signs of infection…

Pig head tongue pirbright

Pirbright and ViroVet join forces to develop African swine fever antivirals

Researchers at The Pirbright Institute will partner with the Belgian biotechnology company ViroVet to develop the first antiviral drugs that act against African swine fever (ASF). In the absence of a vaccine, antiviral drugs could provide an alternative control method which…

bbsrc innovator of the year awards dr andrew broadbent and dr amin asfor

Pirbright innovation recognised at the BBSRC Innovator of the Year Awards

Two scientists from The Pirbright Institute attended the BBSRC Innovator of the Year Awards on 15 May 2019 as shortlisted finalists. Dr Andrew Broadbent and Dr Amin Asfor pitched their research against ten other scientists and groups across four categories: Commercial Impact…

Eggs

Pirbright scientists identify mutation hotspots that may inform infectious bronchitis vaccine development

Scientists at The Pirbright Institute have shown that infectious bronchitis virus (IBV) vaccines produced in eggs have unpredictable mutations which may be prone to reversion in the field. IBV causes a poultry disease which results in large economic losses across the globe…