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A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host

Bluetongue virus (BTV) causes an economically important disease in domestic and wildlife ruminants and is transmitted by Culicoides biting midges. In ruminants, BTV has a wide cell tropism that includes endothelial cells of vascular and lymphatic vessels as important cell…

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Advances in diagnostics, vaccines and therapeutics for Nipah virus

Nipah virus is an emerging zoonotic paramyxovirus that causes severe and often fatal respiratory and neurological disease in humans. The virus was first discovered after an outbreak of encephalitis in pig farmers in Malaysia and Singapore with subsequent outbreaks in…

DNA

Science Spotlight: Dr Mark Fife

Dr Mark Fife and his team are investigating how the genes of host animals and viruses change during infection. This helps them to understand which genes are involved in defending the host from viral attack, which they can use to inform vaccine development. Their work on…

Marek's disease virus (green) with fat molecules (red)

Pirbright scientists show fat is crucial for Marek’s disease virus infection

Scientists at The Pirbright Institute have demonstrated that production and storage of fat is required for Marek’s disease virus (MDV) replication in chickens. Their research identifies new pathways that are involved in the development of the disease which can help generate…

Bulgaria Crimean-Congo Haemorrhagic fever vaccine trial sheep vaccination

Pirbright carries out vaccine trials for Crimean-Congo haemorrhagic fever

After more than two years preparation Dr Nick Lyons and Dr Georgina Limon-Vega from The Pirbright Institute commenced a Crimean-Congo haemorrhagic fever (CCHF) vaccine trial in Bulgaria on 5 March 2019. If successful, this could pave the way for the first licensed vaccine…

young chicken in poultry unit at pirbright

Chicken immune genes could help commercial breeders reduce viral infections

A collaborative study led by The Pirbright Institute and Imperial College London has identified variations in the genes of chicken antiviral proteins called interferon-induced transmembrane proteins (IFITMs) which could have an impact on their ability to fight viral…

The Pirbright Institute Flag raised on a flagpole, billowing in blue sky

New Chair and Trustees join The Pirbright Institute Trustee Board

The Pirbright Institute has announced the appointment of a new Chair of the Trustee Board and several new Trustees. Professor John Stephenson steps up from his position on the Trustee Board to take over as Chair of the Trustee Board from Professor Quintin McKellar CBE, who…

Close up of brown goat face. It has a yellow tag in its ear

Resources

Take a virtual tour of our animal research facilities or browse our animal care and welfare posters.

Annual return of procedures

Each year, we transparently publish data on the animals used in research, ensuring adherence to strict UK regulations.

innovate guildford stand viral survival dr zoo's science lab

Pirbright’s ‘Viral Survival’ travelling science lab a hit at Innovate Guildford 2019

The Pirbright Institute took Dr Zoo’s Travelling Science Lab out on the road for the first time at Innovate Guildford 2019, a local science and arts festival which took place on Saturday 23 March. Visitors entering the ‘Viral Survival’ themed mini escape room were challenged…