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A cell infected by African swine fever virus

Pirbright study identifies African swine fever virus proteins for vaccine development

Scientists at The Pirbright Institute have identified African swine fever virus (ASFV) proteins that can trigger an immune response in pigs. The team hopes to develop a vaccine using these proteins that is capable of protecting against the deadly disease. Published in…

A cell infected by African swine fever virus

Pirbright study identifies African swine fever virus proteins for vaccine development

Scientists at The Pirbright Institute have identified African swine fever virus (ASFV) proteins that can trigger an immune response in pigs. The team hopes to develop a vaccine using these proteins that is capable of protecting against the deadly disease. Published in…

Pirbright destroys final rinderpest virus samples

On 14 June 2019, scientists at The Pirbright Institute destroyed the final archive stocks of rinderpest virus held in the World Reference Laboratory for Rinderpest. This completed a major milestone in the World Organisation for Animal Health ( OIE) and Food and Agriculture…

Pirbright’s ‘Viral Survival’ a huge hit with Cheltenham Science Festival visitors

The Pirbright Institute returned as a festival sponsor to Cheltenham Science Festival between 7 and 9 June 2019. Pirbright’s theme this year was ‘Viral Survival’, which centred on diseases that can spread from animals to people, called zoonoses, and how Pirbright scientists…

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Targeted editing of the pp38 gene in Marek's disease virus-transformed cell lines using CRISPR/Cas9 system

Marek's disease virus (MDV), a lymphotropic alpha-herpesvirus associated with T-cell lymphomas in chickens, is an excellent model for herpesvirus biology and virus-induced oncogenesis. Marek's disease (MD) is also one of the cancers against which a vaccine was first used. In…

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Targeted editing of the pp38 gene in Marek's disease virus-transformed cell lines using CRISPR/Cas9 system

Marek's disease virus (MDV), a lymphotropic alpha-herpesvirus associated with T-cell lymphomas in chickens, is an excellent model for herpesvirus biology and virus-induced oncogenesis. Marek's disease (MD) is also one of the cancers against which a vaccine was first used. In…

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The genetics of life and death: virus-host interactions underpinning resistance to African swine fever, a viral haemorrhagic disease

Pathogen transmission from wildlife hosts to genetically distinct species is a major driver of disease emergence. African swine fever virus (ASFV) persists in sub-Saharan Africa through a sylvatic cycle between warthogs and soft ticks that infest their burrows. The virus…

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Identification of novel epitopes in serotype O foot-and-mouth disease virus by in vitro immune selection

Foot-and-mouth disease virus (FMDV) displays various epitopes on the capsid outer surface. In addition to the five neutralizing antigenic sites, there is evidence of the existence of other, yet unidentified, epitopes that are believed to play a role in antibody-mediated…

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Using the basic reproduction number to assess the risk of transmission of lumpy skin disease virus by biting insects

In recent years, lumpy skin disease virus (LSDV) has emerged as a major threat to cattle outside Africa, where it is endemic. Although evidence suggests that LSDV is transmitted by the bites of blood sucking arthropods, few studies have assessed the risk of transmission…

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African swine fever virus evasion of host defences

African swine fever virus causes a haemorrhagic fever in domestic pigs and wild boar. The continuing spread in Africa, Europe and Asia threatens the global pig industry. The lack of a vaccine limits disease control. To underpin rational strategies for vaccine development…