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Unique collections

Our unique collections play an important role in the study of viral diseases of livestock and are utilised by scientists worldwide.

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Science Technology Platforms

The complex and unique combination of facilities, resources and expertise available at The Pirbright Institute are supported by a number of Science Technology Platforms.

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Pirbright scientists join Outreach Network for Gene Drive Research

The Pirbright Institute has become a member of the Outreach Network for Gene Drive Research, whose mission is to raise awareness with the public about the potential value of this technology. By joining the network, Pirbright scientists will help the public to understand what…

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The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides

Zinc finger antiviral protein (ZAP) is a powerful restriction factor for viruses with elevated CpG dinucleotide frequencies. We report that ZAP similarly mediates antiviral restriction against echovirus 7 (E7) mutants with elevated frequencies of UpA dinucleotides…

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Identification and immunogenicity of African swine fever virus antigens

African swine fever (ASF) is a lethal haemorrhagic disease of domestic pigs for which there is no vaccine. Strains of the virus with reduced virulence can provide protection against related virulent strains of ASFV, but protection is not 100% and there are concerns about the…

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Identification and immunogenicity of African swine fever virus antigens

African swine fever (ASF) is a lethal haemorrhagic disease of domestic pigs for which there is no vaccine. Strains of the virus with reduced virulence can provide protection against related virulent strains of ASFV, but protection is not 100% and there are concerns about the…

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Head start immunity: characterizing the early protection of C strain vaccine against subsequent classical swine fever virus infection

Classical Swine Fever Virus (CSFV) is an ongoing threat to the pig industry due to its high transmission and mortality rates associated with infection. Live attenuated vaccines such as the CSFV C strain vaccine are capable of protecting against infection within 5 days of…

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Replication of Marek's disease virus is dependent on synthesis of de novo fatty acid and prostaglandin E2

Marek's disease virus (MDV) causes deadly lymphoma and induces an imbalance of the lipid metabolism in infected chickens. Here, we discovered that MDV activates fatty acid synthesis (FAS) pathway in primary chicken embryo fibroblasts (CEF). In addition, MDV infected cells…

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Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway

Viruses and bacteria colonize hosts by invading epithelial barriers. Recent studies have shown that interactions between the microbiota, pathogens and the host can potentiate infection through poorly understood mechanisms. Here, we investigated whether diverse bacterial…

Pirbright receives Leader in Openness award

The Pirbright Institute is one of 13 organisations who have been announced as recipients of the first Leader in Openness awards from Understanding Animal Research (UAR). UAR Concordat Leader in Openness award Held for three years, 2019-22, the award recognises Pirbright’s…