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UK-China Centre of excellence for research on avian diseases group photo

UK-China avian disease conference will help enhance food security, says Pirbright scientist

Researchers from The Pirbright Institute and several Chinese institutes gathered in Zhengzhou, China between 23 and 25 September 2019 to attend the annual UK-China Centre of Excellence for Research on Avian Diseases (CERAD) conference. The event also included an opening…

Mosquito taking a blood meal on human skin

Pirbright scientists create mosquito GM method using scorpion venom component

Researchers at The Pirbright Institute have successfully inserted a scorpion venom gene into mosquitoes, which causes their paralysis after they feed on blood. This particular venom component is specific for arthropods, such as insects and millipedes, and harmless to mammals…

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The application of self-limiting transgenic insects in managing resistance in experimental metapopulations

The mass release of transgenic insects carrying female lethal self-limiting genes can reduce pest insect populations. Substantial releases are also a novel resistance management tool, since wild type alleles conferring susceptibility to pesticides can dilute resistance…

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Marek's disease virus-encoded miR-155 ortholog critical for the induction of lymphomas is not essential for the proliferation of transformed cell lines

MicroRNAs (miRNAs) are small non-coding RNAs with profound regulatory roles in many areas of biology, including cancer. MicroRNA 155 (miR-155), one of the extensively studied multifunctional miRNAs, is important in several human malignancies such as diffuse large B cell…

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Marek's disease virus-encoded miR-155 ortholog critical for the induction of lymphomas is not essential for the proliferation of transformed cell lines

MicroRNAs (miRNAs) are small non-coding RNAs with profound regulatory roles in many areas of biology, including cancer. MicroRNA 155 (miR-155), one of the extensively studied multifunctional miRNAs, is important in several human malignancies such as diffuse large B cell…

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An optimized aptamer-binding viral tegument protein VP8 inhibits the production of bovine herpesvirus-1 through blocking nucleocytoplasmic shuttling

Bovine herpesvirus 1 (BoHV-1) is a major pathogen of infectious bovine rhinotracheitis in bovine. Previously, we generated the aptamer IBRV A4 using systemic evolution of ligands by exponential enrichment. This aptamer inhibited infectivity of BoHV-1 by blocking viral…

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Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. It has a positive sense RNA genome that also serves as the mRNA for four non-structural proteins (nsPs) representing subunits of the viral replicase. Coupling of nsP and RNA synthesis complicates analysis of viral RNA…

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Expression of APOBEC3 lentiviral restriction factors in cats

Feline immunodeficiency virus (FIV) is a naturally occurring T-cell tropic lentiviral disease of felids with many similarities to HIV/AIDS in humans. Similar to primate lentiviral-host interactions, feline APOBEC3 (A3) has been shown to inhibit FIV infection in a host…

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Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity

The chicken major histocompatibility complex (MHC) has strong genetic associations with resistance and susceptibility to certain infectious pathogens. The cell surface expression level of MHC class I molecules varies as much as 10-fold between chicken haplotypes and is…

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A rapid RT-LAMP assay for the detection of all four lineages of peste des petits ruminants virus

Peste des petits ruminants (PPR) is a viral disease of small ruminants that is caused by the PPR virus (PPRV) and is a significant burden on subsistence farmers across the developing world. Loop-mediated isothermal amplification (LAMP) provides cost-effective, rapid…