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Pirbright partners with ECO Animal Health to combat poultry diseases

The Pirbright Institute has entered into a worldwide exclusive partnership with ECO Animal Health Ltd (ECO), a wholly owned subsidiary of ECO Animal Health Group plc, on two new projects to combat significant diseases of poultry. The first project, led by Professor Venugopal…

Vaccine being drawn from a vile

Pirbright partners with ECO Animal Health to combat poultry diseases

The Pirbright Institute has entered into a worldwide exclusive partnership with ECO Animal Health Ltd (ECO), a wholly owned subsidiary of ECO Animal Health Group plc, on two new projects to combat significant diseases of poultry. The first project, led by Professor Venugopal…

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Herpesvirus of turkeys (Meleagridis herpesvirus 1) encodes a functional microRNA-221 homolog with high sequence conservation

Herpesviruses account for most of the known virus-encoded miRNAs. Herpesvirus of turkey (HVT), a non-pathogenic avian herpesvirus used as an avian vaccine and viral vector, encodes 28 mature miRNAs. This included HVT-miR-H14-3p that showed almost identical sequence to gga…

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Poultry trading behaviours in Vietnamese live bird markets as risk factors for avian influenza infection in chickens

Vietnamese poultry are host to co-circulating subtypes of avian influenza viruses, including H5N1 and H9N2, which pose a great risk to poultry productivity and to human health. AIVs circulate throughout the poultry trade network in Vietnam, with live bird markets being an…

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MiR-125b suppression inhibits apoptosis and negatively regulates Sema4D in avian leukosis virus-transformed cells

Subgroup J avian leukosis virus (ALV-J), an oncogenic retrovirus, causes hemangiomas and myeloid tumors in chickens. We previously showed that miR-125b is down-regulated in ALV-J-induced tumors. This study aimed to investigate the possible role of miR-125b in ALV-J-mediated…

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Estimating the protection afforded by foot-and-mouth disease vaccines in the laboratory

Foot-and-mouth disease (FMD) vaccines must be carefully selected and their application closely monitored to optimise their effectiveness. This review covers serological techniques for FMD vaccine quality control, including potency testing, vaccine matching and post…

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Rapid detection of peste des petits ruminants virus (PPRV) nucleic acid using a novel low-cost reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for future use in nascent PPR eradication programme

Peste des petits ruminants (PPR) is a disease of small ruminants caused by peste des petits ruminants virus (PPRV), and is endemic in Asia, the Middle East and Africa. Effective control combines the application of early warning systems, accurate laboratory diagnosis and…

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BST2/Tetherin overexpression modulates Morbillivirus glycoprotein production to inhibit cell–cell fusion

The measles virus (MeV), a member of the genus Morbillivirus, is an established pathogen of humans. A key feature of morbilliviruses is their ability to spread by virus–cell and cell–cell fusion. The latter process, which leads to syncytia formation in vitro and in vivo, is…

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Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot

For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes, this process and its…

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SiNPle: fast and sensitive variant calling for deep sequencing data

Current high-throughput sequencing technologies can generate sequence data and provide information on the genetic composition of samples at very high coverage. Deep sequencing approaches enable the detection of rare variants in heterogeneous samples, such as viral quasi…