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Population-level multiplexing, a promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus

CRISPR-based gene drives bias inheritance in their favour by inducing double-stranded breaks (DSBs) at wild-type homologous loci and using the drive transgene as a repair template – converting drive heterozygotes into homozygotes. Recent studies have shown that alternate end…

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Age of first infection across a range of parasite taxa in a wild mammalian population

Newborn mammals have an immature immune system that cannot sufficiently protect them against infectious diseases. However, variation in the effectiveness of maternal immunity against different parasites may couple with temporal trends in parasite exposure to influence…

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The African swine fever virus transcriptome

African Swine Fever Virus (ASFV) causes haemorrhagic fever in domestic pigs, presenting the biggest global threat to animal farming in recorded history. Despite its importance, little is known about the mechanisms and regulation of ASFV transcription. Using RNA sequencing…

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Foot-and-mouth disease virus: prospects for using knowledge of virus biology to improve control of this continuing global threat

Understanding of the biology of foot-and-mouth disease virus (FMDV) has grown considerably since the nucleotide sequence of the viral RNA was determined. The ability to manipulate the intact genome and also to express specific parts of the genome individually has enabled…

Nipah virus particle

Pirbright shows new Nipah vaccines create ‘impressive’ immune response

Scientists at The Pirbright Institute have shown that two new potential vaccines against Nipah virus developed by the University of Parma generate a strong immune response in pigs. These promising results suggest the vaccines could protect pigs against Nipah virus infection…

Anna Ludi and Zahra

Even small acts can help empower women

For International Women’s Day, Dr Anna Ludi reflects on how small acts to support women in science can empower them to take their careers to the next level. According to the International Women’s Day committee this is a day that “marks a call to action for accelerating women…

Goats, sheep and cattle at a Nigerian market

Pirbright estimates the impact of pox viruses on Nigerian farms

Scientists from The Pirbright Institute have shown that outbreaks of lumpy skin disease (LSD), sheeppox and goatpox (SGP) have an immediate and long-lasting impact on the livelihoods of farmers in North-East Nigeria. Researchers analysed data from a study conducted with…

RNA polymerase transcribes RNA from DNA.

Pirbright and UCL scientists map African swine fever genome

Scientists from The Pirbright Institute have worked with UCL to map the expression of genes across the entire African swine fever virus (ASFV) genome, which has helped to establish their order of activation as well as uncovering new genes. The research could provide vital…

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Biological validation and observations of formaldehyde fumigation in operational and representative scenarios in high-containment laboratories

Introduction: The effectiveness of formaldehyde as a fumigant in laboratories, for equipment, and for containment barrier decontamination applications was assessed, in particular the ability to reproduce biological inactivation (6-log reduction) of commercially available…

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Recommendations for the nomenclature of enteroviruses and rhinoviruses

Enteroviruses (EVs) and rhinoviruses (RVs) are significant pathogens of humans and are the subject of intensive clinical and epidemiological research and public health measures, notably in the eradication of poliovirus and in the investigation and control of emerging…