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This scanning electron microscope image shows SARS-CoV-2 (yellow)—also known as 2019-nCoV, the virus that causes COVID-19—isolated from a patient in the U.S., emerging from the surface of cells (pink) cultured in the lab.

Pirbright begins testing new coronavirus vaccines on animals to help combat COVID-19

The Pirbright Institute is joining in the global battle to help control COVID-19 by using its unique expertise and facilities to support the development of vaccines to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the current…

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How to recognise and deal with dubious virus sequences? (Letter to Editor)

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Inactivation of foot-and-mouth disease virus A/IRN/8/2015 with commercially available lysis buffers

Laboratories working with foot-and-mouth disease virus (FMDV) must maintain a high level of biocontainment. However, if infectious virus is reliably inactivated during sample processing, molecular and serological testing can be performed at a lower level of containment. In…

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Generation of a triple insert live avian herpesvirus vectored vaccine using CRISPR/Cas9-based gene editing

Herpesvirus of turkeys (HVT), used originally as a vaccine against Marek’s disease (MD), has recently been shown to be a highly effective viral vector for generation of recombinant vaccines that deliver protective antigens of other avian pathogens. Until the recent launch of…

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An R195K mutation in the PA-X protein increases the virulence and transmission of influenza A virus in mammalian hosts

In the 21(st) century, the emergence of H7N9 and H1N1/2009 influenza viruses originating from animals and causing severe human infections has prompted investigations into the genetic alterations required for cross-species transmission. We previously found that substitution…

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Novel insights in the role of Bcl-1 2 homolog Nr-13 (vNr-13) encoded by herpesvirus of turkeys in the virus replication cycle, mitochondrial networks and apoptosis inhibition

Bcl-2 (B cell lymphoma-2)-related gene Nr-13 plays a major role in the regulation of cell death in developing avian B-cells. With over 65% sequence similarity to the chicken Nr-13, herpesvirus of turkeys (HVT)-encoded HVT079 and HVT096 gene product vNr-13 is the first known…

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Complete coding sequence of a novel bluetongue virus isolated from a commercial sheeppox vaccine

The full genome sequences of two isolates of bluetongue virus (BTV) from a commercial sheeppox vaccine were determined. Strain SPvvvv/02 shows low sequence identity to its closest relative, strain BTV-26 KUW2010/02, indicating the probable detection of a novel BTV genotype…

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Complete coding sequence of a novel bluetongue virus isolated from a commercial sheeppox vaccine

The full genome sequences of two isolates of bluetongue virus (BTV) from a commercial sheeppox vaccine were determined. Strain SPvvvv/02 shows low sequence identity to its closest relative, strain BTV-26 KUW2010/02, indicating the probable detection of a novel BTV genotype…

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Bovine herpesvirus-4-vectored delivery of Nipah virus glycoproteins enhances T cell immunogenicity in pigs

Nipah virus (NiV) is an emergent pathogen capable of causing acute respiratory illness and fatal encephalitis in pigs and humans. A high fatality rate and broad host tropism makes NiV a serious public and animal health concern. There is therefore an urgent need for a NiV…

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Bovine herpesvirus-4-vectored delivery of Nipah virus glycoproteins enhances T cell immunogenicity in pigs

Nipah virus (NiV) is an emergent pathogen capable of causing acute respiratory illness and fatal encephalitis in pigs and humans. A high fatality rate and broad host tropism makes NiV a serious public and animal health concern. There is therefore an urgent need for a NiV…