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Infectious bronchitis virus (IBV)

Infectious bronchitis virus shuts down cell stress signals, Pirbright study shows

A new study from scientists at The Pirbright Institute and collaborators at the University of Surrey provides evidence that infectious bronchitis virus (IBV) can regulate the signals involved in the stress response, which would otherwise prevent a virus from making new…

Female pig in hay inside

Pirbright African swine fever vaccine protects 100% of pigs from developing severe disease

Scientists from The Pirbright Institute are a step closer in the race to develop a vital vaccine for African swine fever (ASF). In their recent trial, published in Vaccines, 100 percent of pigs immunised with the new vaccine survived a lethal dose of ASF virus. ASF causes…

Female pig in hay inside

Pirbright African swine fever vaccine protects 100% of pigs from developing severe disease

Scientists from The Pirbright Institute are a step closer in the race to develop a vital vaccine for African swine fever (ASF). In their recent trial, published in Vaccines, 100 percent of pigs immunised with the new vaccine survived a lethal dose of ASF virus. ASF causes…

Cattle and goats in Tanzania

Host defence genes may contribute to peste des petits ruminants susceptibility

Differences in the host immune response may explain why cattle are less susceptible to peste des petits ruminants (PPR) than goats, according to a collaborative research effort by scientists at The Pirbright Institute and the Tamil Nadu Veterinary and Animal Sciences…

Sheep being moved across the plains in Mongolia by nomadic herders

Pirbright calculates impact of foot-and-mouth disease control in Mongolia

Researchers at The Pirbright Institute have collaborated with State Central Veterinary Laboratories (SCVL) and the General Agency for Veterinary Services (GAVS) in Mongolia to assess the impact of foot-and-mouth disease (FMD) control methods employed during the 2017…

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Frozen evolution of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence

The mechanisms underlying virus emergence are rarely well understood, making the appearance of outbreaks largely unpredictable. Bluetongue virus serotype 8 (BTV-8), an arthropod-borne virus of ruminants, emerged in livestock in northern Europe in 2006, spreading to most…

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Efficient mutagenesis of Marek's disease virus-encoded microRNAs using a CRISPR/Cas9-based gene editing system

The virus-encoded microRNAs (miRNAs) have been demonstrated to have important regulatory roles in herpesvirus biology, including virus replication, latency, pathogenesis and/or tumorigenesis. As an emerging efficient tool for gene editing, the clustered regularly interspaced…

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Full genome sequencing of archived wild type and vaccine rinderpest virus isolates prior to their destruction

When rinderpest virus (RPV) was declared eradicated in 2011, the only remaining samples of this once much-feared livestock virus were those held in various laboratories. In order to allow the destruction of our institute's stocks of RPV while maintaining the ability to…

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GoPrime: development of an in silico framework to predict the performance of real-time PCR primers and probes using foot-and-mouth disease virus as a model

Real-time PCR (rPCR) is a widely accepted diagnostic tool for the detection and quantification of nucleic acid targets. In order for these assays to achieve high sensitivity and specificity, primer and probe-template complementarity is essential; however, mismatches are…

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Genome sequences of foot-and-mouth disease virus O/ME-SA/Ind-2001e strains isolated in Pakistan

The genome sequences of two foot-and-mouth disease type O viruses isolated from outbreaks of disease in cattle in Pakistan in 2019 are described. They were identified as belonging to serotype O, Middle East-South Asia topotype, Ind-2001 lineage, and e sublineage and…