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Pirbright supports UK’s effort to ramp up diagnostic testing for COVID-19

The Pirbright Institute, which is home to several World Reference Laboratories for viral diseases of livestock, is using its equipment and expertise in diagnostics and disease surveillance to support COVID-19 testing in the UK. The Institute is helping in three key areas…

Pirbright supports UK’s effort to ramp up diagnostic testing for COVID-19

The Pirbright Institute, which is home to several World Reference Laboratories for viral diseases of livestock, is using its equipment and expertise in diagnostics and disease surveillance to support COVID-19 testing in the UK. The Institute is helping in three key areas…

Pirbright confirms African horse sickness outbreak in Thailand

Scientists in the Non-Vesicular Reference Laboratory (NVRL) at The Pirbright Institute have confirmed an outbreak of African horse sickness (AHS) in Thailand. AHS is the most lethal viral disease of horses known and the rapid diagnostic services provided by Pirbright has…

Influenza antibodies made by Pirbright reduce disease in chickens

Scientists at The Pirbright Institute have engineered synthetic antibody molecules that can be administered to poultry to reduce the symptoms of influenza, as well as decreasing the amount of influenza virus they shed into the environment. These results suggest that there is…

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Pervasive differential splicing in Marek’s disease virus can discriminate CVI-988 vaccine strain from RB-1B very virulent strain in chicken embryonic fibroblasts

Marek’s disease is a major scourge challenging poultry health worldwide. It is caused by the highly contagious Marek’s disease virus (MDV), an alphaherpesvirus. Here, we showed that, similar to other members of its Herpesviridae family, MDV also presents a complex landscape…

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De novo assembly of the cattle reference genome with single-molecule sequencing

Major advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10-12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated technologies and is hindered by a…

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Eradicating the scourge of peste des petits ruminants from the world

Peste des Petits Ruminants (PPR) is a highly contagious viral disease of both domestic (goats and sheep) and wild ruminants. Caused by a morbillivirus, that belongs to the family Paramyxoviridae. The disease is clinically and pathologically similar to rinderpest of cattle…

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Detection of bovine antibodies against a conserved capsid epitope as the basis of a novel universal serological test for foot-and-mouth disease

Diagnostic tests for foot-and-mouth disease (FMD) include the detection of antibodies against either the viral non-structural proteins or the capsid. The detection of antibodies against the structural proteins (SP) of the capsid can be used to monitor seroconversion in both…

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Detection of bovine antibodies against a conserved capsid epitope as the basis of a novel universal serological test for foot-and-mouth disease

Diagnostic tests for foot-and-mouth disease (FMD) include the detection of antibodies against either the viral non-structural proteins or the capsid. The detection of antibodies against the structural proteins (SP) of the capsid can be used to monitor seroconversion in both…

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Expanding the CRISPR toolbox in Culicine mosquitoes: in vitro validation of Pol III promoters

CRISPR-Cas9-based "gene drive" technologies have been proposed as a novel and effective means of controlling human diseases vectored by mosquitoes. However, more complex designs than those demonstrated to date-and an expanded molecular toolbox with which to build them-will…