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Scientists working on pig and poultry diseases visit Pirbright

On 15 January 2020 The Pirbright Institute hosted Newton Fund Swine and Poultry Research Initiative delegates from the UK, China, Thailand and the Philippines. The projects funded through the initiative have been underway for almost two years and the meeting served as part…

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CCCH-type zinc finger antiviral protein mediates antiviral immune response by activating T cells

The zinc finger antiviral protein (ZAP), as a host restriction factor, inhibits the replication of certain viruses by binding viral mRNA or proteins for degradation. However, little is known about the role of ZAP in the antiviral immune response. We now show that ZAP…

Genetic differences between FMD viruses cause variation in capsid proteins, shown by red dots.

Pirbright scientists shed new light on foot-and-mouth disease virus evolution

New research from The Pirbright Institute has shown that different populations of foot-and-mouth disease virus (FMDV) swap sections of genetic material at a far higher rate than originally thought. The information will help scientists to understand how the frequency of these…

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Laboratory diagnosis of peste des petits ruminants (PPR): Instructor-led

Learn how to isolate PPR virus and apply diagnostic methods.

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In vitro interactions of chicken programmed cell death 1 (PD-1) and PD-1 ligand-1 1 (PD-L1)

In the present study, we determined the in vitro characteristics and binding interactions of chicken PD-1 (chPD-1) and PD-L1 (chPD-L1) and developed a panel of specific monoclonal antibodies against the two proteins. ChPD-1 and chPD-L1 sequence identities and similarities…

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Transboundary movements of foot-and-mouth disease from India to Sri Lanka: A common pattern is shared by serotypes O and C

Foot-and-mouth disease (FMD) affects the livestock industry in a transboundary manner. It is essential to understand the FMD phylodynamics to assist in the disease-eradication. FMD critically affects the Sri Lankan cattle industry causing substantial economic losses. Even…

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The relationship between the presence of antibodies and direct detection of Toxoplasma gondii in slaughtered calves and cattle in four European countries

In cattle, antibodies to Toxoplasma gondii infection are frequently detected, but evidence for the presence of T. gondii tissue cysts in cattle is limited. To study the concordance between the presence of anti- T. gondii IgG and viable tissue cysts of T. gondii in cattle…

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Elucidating cryptic dynamics of Theileria communities in African buffalo using a high-throughput sequencing informatics approach

Increasing access to next-generation sequencing (NGS) technologies is revolutionizing the life sciences. In disease ecology, NGS-based methods have the potential to provide higher-resolution data on communities of parasites found in individual hosts as well as host…

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Pathophysiology of concussive non-penetrative captive bolt stunning of turkeys

The non-penetrative captive bolt (NPCB) has been proposed as a more humane and practical alternative to constant voltage electrical stunning for small-scale seasonal turkey producers. This study evaluated the effectiveness of the CASH ® Small Animal Tool (SAT) (formerly…

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Outbreak of peste des petits ruminants among critically endangered mongolian saiga and other wild ungulates, Mongolia, 2016-2017

The 2016-2017 introduction of peste des petits ruminants virus (PPRV) into livestock in Mongolia was followed by mass mortality of the critically endangered Mongolian saiga antelope and other rare wild ungulates. To assess the nature and population effects of this outbreak…