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Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression

Aedes aegypti and Aedes albopictus mosquitoes are vectors of the RNA viruses chikungunya (CHIKV) and dengue that currently have no specific therapeutic treatments. The development of new methods to generate virus-refractory mosquitoes would be beneficial. Cas13b is an enzyme…

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Timelines of infection and transmission dynamics of H1N1pdm09 in swine

Influenza is a major cause of mortality and morbidity worldwide. The relationship between the time course of influenza infection and virus shedding and onward transmission of the virus remains poorly characterized. Pigs are a natural host for influenza infection with…

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Timelines of infection and transmission dynamics of H1N1pdm09 in swine

Influenza is a major cause of mortality and morbidity worldwide. The relationship between the time course of influenza infection and virus shedding and onward transmission of the virus remains poorly characterized. Pigs are a natural host for influenza infection with…

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Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses

Neuraminidase inhibitors (NAIs) are antiviral agents recommended worldwide to treat or prevent influenza virus infections in humans. Past influenza virus pandemics seeded by zoonotic infection by avian influenza viruses (AIV) as well as the increasing number of human…

M41 infection in primary chicken kidney cell cultures. They have been labelled anti-E (red) and anti-IBV (green) and the nuclei are labelled blue with DAPI.

Pirbright scientists identify new genes in infectious bronchitis virus

Two new genes have been identified in infectious bronchitis virus (IBV), a coronavirus that causes an acute, highly contagious and economically important respiratory disease of poultry. The research, carried out by scientists at The Pirbright Institute, raises the prospect…

M41 infection in primary chicken kidney cell cultures. They have been labelled anti-E (red) and anti-IBV (green) and the nuclei are labelled blue with DAPI.

Pirbright scientists identify new genes in infectious bronchitis virus

Two new genes have been identified in infectious bronchitis virus (IBV), a coronavirus that causes an acute, highly contagious and economically important respiratory disease of poultry. The research, carried out by scientists at The Pirbright Institute, raises the prospect…

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Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus

Coronavirus sub-genomic mRNA (sgmRNA) synthesis occurs via a process of discontinuous transcription involving complementary transcription regulatory sequences (TRSs), one (TRS-L) encompassing the leader sequence of the 5' untranslated region (UTR), and the other upstream of…

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Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus

Coronavirus sub-genomic mRNA (sgmRNA) synthesis occurs via a process of discontinuous transcription involving complementary transcription regulatory sequences (TRSs), one (TRS-L) encompassing the leader sequence of the 5' untranslated region (UTR), and the other upstream of…

default publication image

Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus

Coronavirus sub-genomic mRNA (sgmRNA) synthesis occurs via a process of discontinuous transcription involving complementary transcription regulatory sequences (TRSs), one (TRS-L) encompassing the leader sequence of the 5' untranslated region (UTR), and the other upstream of…

default publication image

Evaluation of cell lines for the isolation of foot-and-mouth disease virus and other viruses causing vesicular disease

The most sensitive cell culture system for the isolation of foot-and-mouth disease virus (FMDV) is primary bovine thyroid (BTY) cells. However, BTY cells are seldom used because of the challenges associated with sourcing thyroids from FMDV-negative calves (particularly in…