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This scanning electron microscope image shows SARS-CoV-2 (yellow)—also known as 2019-nCoV, the virus that causes COVID-19—isolated from a patient in the U.S., emerging from the surface of cells (pink) cultured in the lab.

Pirbright in £10m collaboration to fight animal and plant disease

The Pirbright Institute has joined a £10m advanced technology surveillance programme to strengthen the UK’s biosecurity and protect animals, plants, people and trade. Advanced genome sequencing technologies - a method that reads the complete genetic code of a living organism…

Grants Administrator

The Pirbright Institute delivers world-leading research to understand, predict, detect, and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies…

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Multi-omics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells

Brain tumours disproportionately affect children and are the largest cause of paediatric cancer-related death. Novel therapies that engage the immune system, such as oncolytic viruses (OVs), hold great promise and are desperately needed. Zika virus (ZIKV) infects and…

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Direct amplification and sequencing of enterovirus genomes from clinical and wastewater samples reveals uncommon virus types in Cameroon

Knowledge about the genetic diversity of enteroviruses in sub-Saharan Africa remains biased by the fact that it has mainly been described through the characterization of specimens isolated in cell cultures. The aim of this study was to characterize enteroviruses that…

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Foot-and-Mouth Disease Vaccines by Design; Production of Capsid-Modified Foot-and-Mouth Disease Viruses with Improved Cell Culture Growth

Background/objectives: Vaccination is important for controlling foot-and-mouth disease (FMD) in endemic regions and to lessen the effects of outbreaks in FMD-free countries. The adaptation of FMD virus to BHK cells is a necessary but time-consuming and costly step in vaccine…

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Porcine respiratory coronavirus as a model for acute respiratory disease: mechanisms of different infection outcomes

Porcine respiratory coronavirus (PRCV) is a naturally occurring pneumotropic coronavirus in the pig, providing a valuable large animal model to study acute respiratory disease. PRCV pathogenesis and the resulting immune response were investigated in pigs, the natural large…

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SARS-CoV-2 variants retain high airborne transmissibility by different strategies

SARS-CoV-2 variants evolve to balance immune evasion and airborne transmission, yet the mechanisms remain unclear. In hamsters, first-wave, Alpha, and Delta variants transmitted efficiently via aerosols. Alpha emitted fewer viral particles than first-wave virus but…

Close up of two pink pigs lying on straw

Pigs provide insights into coronavirus-induced lung damage

Respiratory viruses are a major threat to global health, but why some people experience severe lung damage from infections like SARS-CoV-2 while others have mild symptoms is something that researchers have sought to understand. A new study lead by Pirbright researchers uses…

Graduate Engineer

The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies…

Group of six pink pigs on straw

Animal trials underway in quest for African swine fever vaccine

A vaccine candidate for African swine fever (ASF) is undergoing tests at The Pirbright Institute. Developed in partnership between the Institute and The Vaccine Group (TVG), the candidate is being clinically trialled in vaccinated pigs. “Vaccinated pigs will be challenged…