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Research paper

Interferon-gamma influences immunity elicited by vaccines against very virulent Marek's disease virus

Vaccination of chickens with herpesvirus of turkey (HVT) confers only partial protection against challenge with a very virulent Marek's disease virus (MDV). Here, we evaluated the ability of recombinant chicken interferon-gamma (rChIEN-gamma) to enhance protective efficacy…
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Research paper

Field performance of engineered male mosquitoes

Dengue is the most medically important arthropod-borne viral disease, with 50-100 million cases reported annually worldwide(1). As no licensed vaccine or dedicated therapy exists for dengue, the most promising strategies to control the disease involve targeting the…
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Research paper

Salmonella enterica serovar Typhimurium colonizing the lumen of the chicken intestine grows slowly and upregulates a unique set of virulence and metabolism genes

The pattern of global gene expression in Salmonella enterica serovar Typhimurium bacteria harvested from the chicken intestinal lumen (cecum) was compared with that of a late-log-phase LB broth culture using a whole-genome microarray. Levels of transcription, translation…
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Research paper

Characterization of age-related changes in bovine CD8(+) T-cells

Evaluation of the changes induced by immunological interventions requires a baseline against which to compare those changes. The age-related changes in the CD8+ T-cell population of cattle were studied. The results indicate that CD8+ T-cells could be divided into ?/? TCR1+…
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Research paper

Inhibition of interferon induction and action by the nairovirus Nairobi sheep disease virus/Ganjam virus

The Nairoviruses are an important group of tick-borne viruses that includes pathogens of man (Crimean Congo hemorrhagic fever virus) and livestock animals (Dugbe virus, Nairobi sheep disease virus (NSDV)). NSDV is found in large parts of East Africa and the Indian…
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Research paper

Identification of surrogates and correlates of protection in protective immunity against Mycobacterium bovis infection induced in neonatal calves by vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish

Vaccination of neonatal calves with Mycobacterium bovis bacillus Calmette-Guérin (BCG) induces a significant degree of protection against infection with virulent M. bovis, the causative agent of bovine tuberculosis (bTB). We compared two strains of BCG, Pasteur and Danish…
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Research paper

Proteomic patterns as biomarkers for the early detection of schistosomiasis japonica in a rabbit model

The objective of this study was to identify proteomic patterns in sera for the early detection of Schistosoma japonicum infections in a rabbit model. Proteomic patterns were to be established by profiling serum proteins using magnetic bead (MB) separation and matrix assisted…
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Research paper

The UNC-4 homeobox protein represses mab-9 expression in DA motor neurons in Caenorhabditis elegans

The T-box transcription factor mab-9 has been shown to be required for the correct fate of the male-specific blast cells B and F, normal posterior hypodermal morphogenesis, and for the correct axon migration of motor neurons that project circumferential commissures to dorsal…
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Research paper

Evaluation of matrix-assisted laser desorption/ionization time of flight mass spectrometry for characterization of Culicoides nubeculosus biting midges

Matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) has shown promise in species identification of insect species. We evaluated its potential to consistently characterize laboratory-reared biting midges of the species Culicoides…
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Research paper

Comparison of the epidemiology of epizootic haemorrhagic disease and bluetongue viruses in dairy cattle in Israel

An outbreak of epizootic haemorrhagic disease virus (EHDV) in cattle in Israel in 2006 enabled a comparison of the spatial distribution of epidemic exposure to EHDV with that of exposure to bluetongue virus (BTV), which is endemic in the country. The seroprevalence of both…
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