Researchers at The Pirbright Institute have shown that when drugs are used to inhibit the cellular protein, hsp90, foot-and-mouth disease virus (FMDV) production is reduced. Hsp90 is a protein used by cells to fold other proteins correctly and it was shown to be required by FMDV to form the outer shell of the virus which protects the viral genome. This provides new insights into how FMDV replicates during infection, and also demonstrates the potential for hsp90 as a target for future FMD antiviral treatments.
On Monday 4 December, The Pirbright Institute jointly won the Public Engagement category at the fourth annual Understanding Animal Research (UAR) Openness Awards for its contribution to the 360° Laboratory Animal Tours project. The Openness Awards mark the efforts of UK research facilities to be transparent about their use of animals in research, and recognise the innovative ways they are communicating with the public.
Scientists from The Pirbright Institute, in collaboration with others, have found immune cells designed to help clear infections could actually be aggravating respiratory disease caused by bovine respiratory syncytial virus (BRSV). The virus infects the lungs of cattle and is closely related to human respiratory syncytial virus (HRSV), which mostly affects infants but can also cause longer term complications such as asthma.