Sheep and goat pox virus

The sheeppox virus (SPPV) and goatpox virus (GTPV) are contagious viral skin diseases of sheep and goats. They are members of the Poxviridae, genus Capripoxvirus and were believed to be strains of the same virus, but genetic sequencing has shown they are closely related separate viruses. Some strains are able to infect both sheep and goats whilst others are host specific. Recombination can also occur between sheep and goat strains, creating a range of host preferences and virulence. Both viruses possess an envelope, capsid and double stranded DNA genome.  

  • Sheeppox and goatpox are notifiable diseases and should be reported.
    Please see the Defra website for advice on how to spot and report the disease.

Associated diseases:

SPPV and GTPV cause pox in sheep and goats. The virus is found in saliva, secretions from the nose, eyes, milk, urine and faeces. Scabs from the skin lesions are also infectious and can survive in the environment. Clinical signs vary with younger animals being more severely affected.

Clinical signs:

  • Fever
  • Red spots that become blisters on the muzzle, eyelids, ears, udder or in severe cases all over the body.
  • Lesions can develop internally causing breathing difficulties
  • Lethargy
  • Depression
  • Reluctance to feed
  • Eye and nose discharge or swollen eyelids
  • Death (5-10% in endemic areas, approaching 100% in imported animals)

Disease transmission:

Animals can be infected by direct contact with infected animals or indirectly through contaminated objects (fomites) such as clothing or footwear. The virus is also present in respiratory aerosols and can be spread by close contact and by insects.

Disease prevalence:

Sheeppox and goatpox can be found in Africa, Asia, the Middle East, India and also Greece.

Impact for Society – what are we doing?

The Non-Vesicular Disease Reference Laboratory at the Institute provides a referencing lab for SPPV and GTPV. This aids in the identification of strains should there be an outbreak.

Research papers

Murray L, Edwards L, Tuppurainen E S M, Bachanek-Bankowska K, Oura C A L, Mioulet V, King D P (2013)

BMC Veterinary Research 9 , 90
Gelaye E, Lamien C E, Silber R, Tuppurainen E S M, Grabherr R, Diallo A (2013)

PLoS ONE 8 (10) , e75971
Tuppurainen E S M, Pearson C R, Bachanek-Bankowska K, Knowles N J, Amareen S, Frost L, Henstock M R, Lamien C E, Diallo A, Mertens P P C (2014)

Antiviral Research 109 (0) , 1-6
Abutarbush S M, Hananeh W M, Ramadan W, Al Sheyab O M, Alnajjar A R, Al Zoubi I G, Knowles N J, Bachanek-Bankowska K, Tuppurainen E S (2015)

Transboundary and Emerging Diseases 63 (2) , e213-e219


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