Infectious bronchitis virus

Infectious bronchitis virus (IBV) is a highly infectious avian pathogen which affects the respiratory tract, gut, kidney and reproductive systems. It belongs to the Coronavirus family, genus Gammacoronavirus which has a single stranded RNA genome, surrounded by a nucleocapsid and envelope.

Associated diseases:

IBV causes infectious bronchitis, targeting the respiratory and uro-genital tract. IBV mainly causes respiratory disease in the infected birds but also lowers egg production, and can cause kidney damage.

Clinical signs:

  • Young chickens are depressed and huddle under the heat source
  • Gasping, coughing and nasal discharge
  • Drop in egg production
  • Poor quality eggs; misshapen or soft-shelled eggs with watery content
  • When the kidneys are affected, increased water intake, depression, scouring and wet litter are commonly observed.

Disease spread:

IBV is spread by aerosol or by ingestion of contaminated feed, water or faeces. Contaminated equipment and material are also a potential source for indirect transmission over large distances.

Disease prevalence:

IBV is globally spread, being prevalent in all countries with an intensive poultry industry.

Impact for Society – what are we doing?

In spite of available vaccines, IBV is a major problem for the global poultry industry. Work at the Institute is focused on studying the function of individual genes which give us a better understanding of the disease and how to design better vaccines.

Collaborations with pharmaceutical companies have been taking place to create novel designs for vaccines. The poultry industry and farmers have benefitted from improved understanding of the disease and the continued investment into new vaccines will reduce financial losses.

Research papers

Keep S M, Bickerton E, Britton P (2015)

Coronaviruses: Methods and Protocols (edited by H J Maier, E Bickerton and P Britton, Humana Press) (1282) , 109-112
Kint J, Fernandez-Gutierrez M, Maier H J, Britton P, Langereis M A, Koumans J, Wiegertjes G F, Forlenza M (2015)

Journal of Virology 89 (2) , 1156-1167
Kint J, Dickhout A, Kutter J, Maier H J, Britton P, Koumans J, Pijlman G P, Fros J J, Wiegertjes G F, Forlenza M (2015)

Journal of Virology 89 (23) , 12047-12057
Valastro V, Holmes E C, Britton P, Fusaro A, Jackwood M W, Cattoli G, Monne I (2016)

Infection, Genetics and Evolution 39 , 349-364


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