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Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines

Global vaccination programs using live-attenuated oral and inactivated polio vaccine (OPV and IPV) have almost eradicated poliovirus (PV) but these vaccines or their production pose significant risk in a polio-free world. Recombinant PV virus-like particles (VLPs), lacking…

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Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines

Global vaccination programs using live-attenuated oral and inactivated polio vaccine (OPV and IPV) have almost eradicated poliovirus (PV) but these vaccines or their production pose significant risk in a polio-free world. Recombinant PV virus-like particles (VLPs), lacking…

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The bird's immune response to avian pathogenic Escherichia coli

Avian pathogenic Escherichia coli (APEC) cause colibacillosis in birds, a syndrome of severe respiratory and systemic disease that constitutes a major threat due to early mortality, condemnation of carcasses and reduced productivity. APEC can infect different types of birds…

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Unpicking the secrets of African swine fever viral replication sites

African swine fever virus (ASFV) is a highly contagious pathogen which causes a lethal haemorrhagic fever in domestic pigs and wild boar. The large, double-stranded DNA virus replicates in perinuclear cytoplasmic replication sites known as viral factories. These factories…

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Unpicking the secrets of African swine fever viral replication sites

African swine fever virus (ASFV) is a highly contagious pathogen which causes a lethal haemorrhagic fever in domestic pigs and wild boar. The large, double-stranded DNA virus replicates in perinuclear cytoplasmic replication sites known as viral factories. These factories…

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Thermal limits for flight activity of field-collected Culicoides in the United Kingdom defined under laboratory conditions

BACKGROUND: Culicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of internationally important arboviruses and inflict biting nuisance on humans, companion animals and livestock. In temperate regions, transmission of arboviruses is limited by temperature…

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Thermal limits for flight activity of field-collected Culicoides in the United Kingdom defined under laboratory conditions

BACKGROUND: Culicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of internationally important arboviruses and inflict biting nuisance on humans, companion animals and livestock. In temperate regions, transmission of arboviruses is limited by temperature…

default publication image

Thermal limits for flight activity of field-collected Culicoides in the United Kingdom defined under laboratory conditions

BACKGROUND: Culicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of internationally important arboviruses and inflict biting nuisance on humans, companion animals and livestock. In temperate regions, transmission of arboviruses is limited by temperature…

African swine fever virus factory showing virus particles forming in red.

Stunning images allow Pirbright scientists to unpick the secrets of African swine fever viral replication

Transmission electron microscope image of a viral factory showing new virions amongst dense protein/membrane accumulationsDeveloping effective vaccines and treatments against African swine fever virus (ASFV), which kills up to 100 percent of the pigs it infects, has been…

African swine fever virus factory showing virus particles forming in red.

Stunning images allow Pirbright scientists to unpick the secrets of African swine fever viral replication

Transmission electron microscope image of a viral factory showing new virions amongst dense protein/membrane accumulationsDeveloping effective vaccines and treatments against African swine fever virus (ASFV), which kills up to 100 percent of the pigs it infects, has been…