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Cows in a Bangladesh market

Landmark study by Pirbright uncovers crucial details of lumpy skin disease virus transmission by insects

Scientists at The Pirbright Institute have measured the risk of different insect species transmitting lumpy skin disease virus (LSDV) for the first time. LSDV causes severe disease in cattle and is rapidly emerging into new regions. It has recently spread from Africa and the…

Cows in a Bangladesh market

Landmark study by Pirbright uncovers crucial details of lumpy skin disease virus transmission by insects

Scientists at The Pirbright Institute have measured the risk of different insect species transmitting lumpy skin disease virus (LSDV) for the first time. LSDV causes severe disease in cattle and is rapidly emerging into new regions. It has recently spread from Africa and the…

Cows in a Bangladesh market

Landmark study by Pirbright uncovers crucial details of lumpy skin disease virus transmission by insects

Scientists at The Pirbright Institute have measured the risk of different insect species transmitting lumpy skin disease virus (LSDV) for the first time. LSDV causes severe disease in cattle and is rapidly emerging into new regions. It has recently spread from Africa and the…

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Development of polymorphic markers in the immune gene complex loci of cattle

The addition of cattle health and immunity traits to genomic selection indices holds promise to increase individual animal longevity and productivity, and decrease economic losses from disease. However, highly variable genomic loci that contain multiple immune-related genes…

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Discovery of Sisunatovir (RV521), an inhibitor of respiratory syncytial virus fusion

RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits that originated from a physical property directed hit profiling exercise at Reviral. This exercise encompassed…

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Understanding what shapes disease control: An historical analysis of foot-and-mouth disease in Kenya

Interpreting the interplay between politics, social demographics and epidemiology is essential for understanding how a disease's occurrence and control evolve over time. Foot-and-mouth disease (FMD) virus was first detected in Kenya in 1915 and serotyped in 1932. This review…

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Understanding what shapes disease control: An historical analysis of foot-and-mouth disease in Kenya

Interpreting the interplay between politics, social demographics and epidemiology is essential for understanding how a disease's occurrence and control evolve over time. Foot-and-mouth disease (FMD) virus was first detected in Kenya in 1915 and serotyped in 1932. This review…

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Prospects of COVID-19 vaccination in Romania: challenges and potential solutions

The rapid advancement in vaccine development represents a critical milestone that will help humanity tackle the COVID-19 pandemic. However, the success of these efforts is not guaranteed, as it relies on the outcomes of national and international vaccination strategies. In…

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Identification and phenotype of MAIT cells in cattle and their response to bacterial infections

Mucosal-associated invariant T (MAIT) cells are a population of innate-like T cells that utilize a semi-invariant T cell receptor (TCR) α chain and are restricted by the highly conserved antigen presenting molecule MR1. MR1 presents microbial riboflavin biosynthesis derived…

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Application of error-prone PCR to functionally probe the morbillivirus Haemagglutinin protein

The enveloped morbilliviruses utilise conserved proteinaceous receptors to enter host cells: SLAMF1 or Nectin-4. Receptor binding is initiated by the viral attachment protein Haemagglutinin (H), with the viral Fusion protein (F) driving membrane fusion. Crystal structures of…