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Securing our future: the value of veterinary vaccines, IVNN and BSI report cover

Veterinary vaccinology report sets out key recommendations to ensure future readiness for disease threats

Today the British Society for Immunology (BSI) and the International Veterinary Vaccinology Network (IVVN) have published 'Securing our future: the value of veterinary vaccines'. The joint report lays out the current veterinary vaccinology landscape, identifies threats to…

Newcastle disease virus bioimage

Newcastle disease (ND): eLearning

Learn about Newcastle disease virus, how it spreads and clinical signs.

A map showing the spread of foot-and-mouth disease virus variants across Asia

Pirbright study identifies risk factors that drive FMD outbreaks in Asia

https://www.youtube.com/watch?v=KYOC83wA3DA An international project led by scientists in the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD) at The Pirbright Institute has tracked the evolution of FMD virus (FMDV) over nearly 20 years to reveal how different…

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nsP4 is a major determinant of alphavirus replicase activity and template selectivity

Alphaviruses have positive-strand RNA genomes containing two open reading frames (ORFs). The first ORF encodes the non-structural (ns) polyproteins P123 and P1234 that act as precursors for the subunits of the viral RNA replicase (nsP1-nsP4). Processing of P1234 leads to the…

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Development of nanobodies targeting peste des petits ruminants virus: the prospect in disease diagnosis and therapy

Peste des petits ruminants virus (PPRV) causes a highly devastating disease, peste des petits ruminants (PPR) of sheep and goats, that threatens food security, small ruminant production, and the conservation of wild small ruminants in many developing countries, especially in…

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Deletion of the K145R and DP148R genes from the virulent ASFV Georgia 2007/1 isolate delays the onset, but does not reduce severity, of clinical signs in infected pigs

African swine fever virus causes a frequently fatal disease of domestic pigs and wild boar that has a high economic impact across 3 continents. The large double-stranded DNA genome codes for approximately 160 proteins. Many of these have unknown functions and this hinders…

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ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of this phenomena is warranted for vaccine development against SARS CoV-2. Here we report detailed…

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Subpopulations of swine γδ T cells defined by TCRγ and WC1 gene expression

γδ T cells constitute a major portion of lymphocytes in the blood of both ruminants and swine. Subpopulations of swine γδ T cells have been distinguished by CD2 and CD8α expression. However, it was not clear if they have distinct expression profiles of their T-cell receptor…

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Engineered promoter-switched viruses reveal the role of poxvirus maturation protein A26 as a negative regulator of viral spread

Vaccinia virus produces two types of virions known as single-membraned intracellular mature virus (MV) and double-membraned extracellular enveloped virus (EV). EV production peaks earlier when initial MV are further wrapped and secreted to spread infection within the host…

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The selection of naturally stable candidate foot-and-mouth disease virus vaccine strains for East Africa

Foot-and-mouth disease (FMD) is a global burden on the livestock industry. The causative agent, FMD virus (FMDV), is highly infectious and exists in seven distinct serotypes. Vaccination remains the most effective control strategy in endemic regions and current FMD vaccines…