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Science spotlight: Pirbright’s female scientists leading the way in new funding

Seven of Pirbright’s scientists have had upcoming projects funded by UKRI through the BBSRC Impact Acceleration Account (IAA). These scientists have several qualities in common: scientific know-how, experience in leading projects, and the fact they are all women. The IAA…

A novel way to create vaccines against infectious bronchitis virus explored by Pirbright scientists

Researchers at The Pirbright Institute have developed a potential vaccine for infectious bronchitis virus (IBV) that could protect chickens from severe disease with just one dose. IBV is a coronavirus that causes a highly contagious disease in poultry, it results in…

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A systematic review of equid welfare at slaughter

Guidance surrounding equine slaughter varies globally and lacks published evidence, limiting practical application, causing industry confusion and potentially compromised welfare at all stages of the slaughter process, both ante- and post-mortem. Existing research in this…

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Cellular and humoral immune responses after immunisation with low virulent African swine fever virus in the large white inbred Babraham line and outbred domestic pigs

African swine fever virus is currently present in all of the world's continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine. The Babraham large white pig is a highly inbred line that could represent a…

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Cellular and humoral immune responses after immunisation with low virulent African swine fever virus in the large white inbred Babraham line and outbred domestic pigs

African swine fever virus is currently present in all of the world's continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine. The Babraham large white pig is a highly inbred line that could represent a…

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Membrane interactions and uncoating of Aichi virus: a picornavirus that lacks a VP4

Kobuviruses are an unusual and poorly characterized genus within the picornavirus family and can cause gastrointestinal enteric disease in humans, livestock, and pets. The human kobuvirus Aichi virus (AiV) can cause severe gastroenteritis and deaths in children below the age…

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Cross-Serotype reactivity of ELISAs used to detect antibodies to the structural proteins of foot-and-mouth disease virus

Antibodies to the foot-and-mouth disease virus (FMDV) capsid induced by infection or vaccination can provide serotype-specific protection and be measured using virus neutralization tests and viral structural-protein (SP-)ELISAs. Separate tests are needed for each serotype…

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Clinical, virological, imaging and pathological findings in a SARS CoV-2 antibody positive cat

This paper reports a presumptive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a cat. A cat with respiratory disease living with three individuals with coronavirus disease 2019 showed bilateral ground-glass opacities in the lung on X-ray and…

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Towards reverse vaccinology for bovine TB: high throughput expression of full length recombinant Mycobacterium bovis proteins

Bovine tuberculosis caused by Mycobacterium bovis, is a significant global pathogen causing economic loss in livestock and zoonotic TB in man. Several vaccine approaches are in development including reverse vaccinology which uses an unbiased approach to select open reading…

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Viral dynamics and immune responses to foot-and-mouth disease virus in African buffalo (Syncerus caffer)

Foot-and-mouth disease (FMD) is one of the most important livestock diseases restricting international trade. While African buffalo ( Syncerus caffer) act as the main wildlife reservoir, viral and immune response dynamics during FMD virus acute infection have not been…