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Investigating the RelA Gene's role in African Swine fever tolerance: a study of Indian pigs

African Swine Fever (ASF) is a highly contagious transboundary viral disease affecting domestic pigs worldwide, often resulting in nearly 100 % mortality due to the lack of effective vaccines. However, wild species such as warthogs (Phacochoerus sp.) and bush pigs…

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An antigen panel to assess the regional relevance of foot and mouth disease vaccines

Despite widespread use of inactivated vaccines to control foot-and-mouth disease (FMD), there is no systematic approach to demonstrate the regional relevance of these products against the specific serotypes and strains that circulate in endemic countries in Africa and Asia…

Sheep being moved across the plains in Mongolia by nomadic herders

Pirbright calculates impact of foot-and-mouth disease control in Mongolia

Researchers at The Pirbright Institute have collaborated with State Central Veterinary Laboratories (SCVL) and the General Agency for Veterinary Services (GAVS) in Mongolia to assess the impact of foot-and-mouth disease (FMD) control methods employed during the 2017…

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Foot-and-mouth disease virus O/ME-SA/SA-2018: A new emerging threat posed by viruses circulating in Asia?

In 2018, a novel lineage of foot-and-mouth disease virus (FMDV) termed O/ME-SA/SA-2018 was identified in India, which subsequently spread into neighbouring countries (Nepal, Bangladesh and Sri Lanka). Since then, incursions of this lineage have occurred in the Middle East…

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Estimating population immunity to SARS-CoV-2 by random sampling from primary and secondary healthcare in Scotland, May 2024

Background: As the COVID-19 pandemic has ended, the global focus has shifted from "pandemic response" to "long-term management". With no ongoing nationwide serosurveillance studies, our understanding of the level of immunity in the general population has diminished. In this…

Female pig in hay inside

Pirbright African swine fever vaccine protects 100% of pigs from developing severe disease

Scientists from The Pirbright Institute are a step closer in the race to develop a vital vaccine for African swine fever (ASF). In their recent trial, published in Vaccines, 100 percent of pigs immunised with the new vaccine survived a lethal dose of ASF virus. ASF causes…

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Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs

Tissue-resident memory (TRM) T cells play an important role in protection against respiratory infection but whether this memory is maintained by long-lived or dividing cells remains controversial. To address the rate of division of lung TRM T cells, deuterium-enriched water…

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Vaccination and surveillance for high pathogenicity avian influenza in poultry-current situation and perspectives

The International Alliance for Biological Standardization (IABS), in collaboration with the World Organization for Animal Health (WOAH) convened a hybrid meeting on 22-23 October 2024 at the WOAH Headquarters (HQ) in Paris, France to discuss the global state of vaccination…

Infectious bronchitis virus (IBV)

Infectious bronchitis virus shuts down cell stress signals, Pirbright study shows

A new study from scientists at The Pirbright Institute and collaborators at the University of Surrey provides evidence that infectious bronchitis virus (IBV) can regulate the signals involved in the stress response, which would otherwise prevent a virus from making new…

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Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX

African swine fever virus originated in a wildlife cycle in East Africa and spread to domestic pigs. At least twenty-three genotypes are present in Africa whereas only genotypes I and II have spread to other continents. Vaccine development has been directed mainly to…