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We have developed a reverse genetics system for the avian coronavirus infectious bronchitis virus (IBV) in which a full-length cDNA corresponding to the IBV genome is inserted into the vaccinia virus genome under the control of a T7 promoter sequence. Vaccinia virus as a…

Peste des petits ruminants (PPR) is an acute and highly contagious viral disease of sheep, goats and wild ruminants. The disease is controlled by the use of live-attenuated vaccines that give a lifelong immunity. Currently, several PPR vaccines are available for use in the…

Cross-reactivity between Babesia bovis and B. bigemina becomes a problem in discrimination of the two infections in endemic areas where the two species usually occur in association. With the aim of identifying candidate proteins for use as specific diagnostic tools, culture…

The first part of this study of the biology Cal mechanisms underlying attenuation of virulent Theileria annulata macroschizont-infected cell Lines screened four pairs of T. annulata (Hisar) in vivo- and in vitro-derived macroschizont-infected cell Lines (lines) and…

In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3'…

A clinical trial testing the prophylactic effect of a 5 mg kg(-1) dose of buparvaquone on either Theileria annulata or Theileria parva experimental infections of calves demonstrated its efficacy for periods of at least seven days. The drug given 1 h or seven days before 50%…

We have investigated the role of specific components of the thymic stroma during development of CD4(-)8(-) T cell precursors by separating and reaggregating precursor subsets with individual or combinations of stromal cells. We show that while the development of CD25(+) 44(+…

The adenovirus protease requires activation by an 11-residue peptide, GVQSLKRRRCF, to achieve maximum proteolytic activity. Derived from the C terminus of the viral protein pVI, the activating peptide (pVI-CT) forms a disulfide bond with cysteine 104 of the protease and…

We have shown that an antibody (9C10) to the alpha 4 integrin induces apoptosis in murine immature CD4(+) CD8(+) thymocytes and in activated (but not resting) mature lymph node T cells. In both cases, apoptosis is blocked by the highly selective protein kinase C (PKC)…

Heartwater, an often fatal rickettsial disease of domestic ruminants transmitted by Amblyomma variegatum ticks, ranks with the A. variegatum-associated skin disease dermatophilosis as a major constraint to the upgrading of livestock productivity in Ghana. An epidemiological…