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Thymic depletion of lymphocytes is associated with the virulence of PRRSV-1 strains

Porcine reproductive and respiratory syndrome virus (PRRSV) exists as two distinct viruses, type 1 (PRRSV-1) and type 2 (PRRSV-2). Atrophy of the thymus in PRRSV-2 infected piglets has been associated with a loss of thymocytes. The present study aimed to evaluate the impact…

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Type I and III IFNs produced by plasmacytoid dendritic cells in response to a member of the Flaviviridae suppress cellular immune responses

The pestivirus noncytopathic bovine viral diarrhea virus (BVDV) can suppress IFN production in the majority of cell types in vitro. However, IFN is detectable in serum during acute infection in vivo for ∼5–7 d, which correlates with a period of leucopoenia and…

World Veterinary Day 2016

World Veterinary Day is a globally recognised event which highlights the veterinary profession and its contribution to the health of both animals and humans. This year it takes place on Saturday 30 April and is themed 'Continuing education with a One Health focus'. Launched…

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The Institute showcases its scientific excellence to Brazilian trade delegation

The Pirbright Institute recently hosted a visit by a Brazilian trade delegation to showcase the excellence of its science, and explore the opportunities for new collaboration. The visit which included members from Brazil’s veterinary, scientific and agricultural sectors was…

International partnership to develop FMD detection kits

The Pirbright Institute has signed an international partnership agreement with IZSLER, the leading Italian animal disease research body, to jointly produce cutting edge diagnostic kits for foot-and-mouth disease (FMD). The new kits have been evaluated for excellent…

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Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation

Pigs are evidently more resistant to avian than swine influenza A viruses, mediated in part through frontline epithelial cells and alveolar macrophages (AM). Although porcine AM (PAM) are crucial in influenza virus control, their mode of control is unclear. To gain insight…

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A vision of KIR variation at super resolution

The 9th killer cell immunoglobulin-like receptor (KIR) workshop was held in Winchester, United Kingdom late in the summer of 2015. The extraordinary diversity of KIR and its functional consequences were key themes throughout the meeting. Novel sequencing technologies and new…

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An ontology for major histocompatibility restriction

MHC molecules are a highly diverse family of proteins that play a key role in cellular immune recognition. Over time, different techniques and terminologies have been developed to identify the specific type(s) of MHC molecule involved in a specific immune recognition context…

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Expression of a second open reading frame present in the genome of tick-borne encephalitis virus strain Neudoerfl is not detectable in infected cells

A short upstream open reading frame (uORF) was recently identified in the 5? untranslated region of some tick-borne encephalitis virus (TBEV) strains. However, it is not known if the peptide encoded by TBEV uORF (TuORF) is expressed in infected cells. Here we show that TuORF…